Biophysical Studies on Interactions and Assembly of Full-size E3 Ubiquitin Ligase: SUPPRESSOR OF CYTOKINE SIGNALING 2 (SOCS2)-ELONGIN BC-CULLIN 5-RING BOX PROTEIN 2 (RBX2)

par Bulatov, Emil, Martin, Esther M., Chatterjee, Sneha, Knebel, Axel, Shimamura, Satoko, Konijnenberg, Albert, Johnson, Clare, Zinn, Nico, Grandi, Paola, Sobott, Frank, Ciulli, Alessio
Publié dans J Biol Chem (2015)

Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons

par Ramsden, Nigel, Perrin, Jessica, Ren, Zhao, Lee, Byoung Dae, Zinn, Nico, Dawson, Valina L., Tam, Danny, Bova, Michael, Delling, Manja, Drewes, Gerard, Bantscheff, Marcus, Bard, Frederique, Dawson, Ted M., Hopf, Carsten
Publié 2011

Systematic analysis of protein turnover in primary cells

par Mathieson, Toby, Franken, Holger, Kosinski, Jan, Kurzawa, Nils, Zinn, Nico, Sweetman, Gavain, Poeckel, Daniel, Ratnu, Vikram S., Schramm, Maike, Becher, Isabelle, Steidel, Michael, Noh, Kyung-Min, Bergamini, Giovanna, Beck, Martin, Bantscheff, Marcus, Savitski, Mikhail M.
Publié dans Nat Commun (2018)

CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model

par Cansfield, Andrew D., Ladduwahetty, Tammy, Sunose, Mihiro, Ellard, Katie, Lynch, Rosemary, Newton, Anthea L., Lewis, Ann, Bennett, Gavin, Zinn, Nico, Thomson, Douglas W., Rüger, Anne J., Feutrill, John T., Rausch, Oliver, Watt, Alan P., Bergamini, Giovanna
Publié dans ACS Med Chem Lett (2016)

Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor

par Thomson, Douglas W., Poeckel, Daniel, Zinn, Nico, Rau, Christina, Strohmer, Katrin, Wagner, Anne J., Graves, Alan P., Perrin, Jessica, Bantscheff, Marcus, Duempelfeld, Birgit, Kasparcova, Viera, Ramanjulu, Joshi M., Pesiridis, G. Scott, Muelbaier, Marcel, Bergamini, Giovanna
Publié dans ACS Med Chem Lett (2019)

An integrated multiomic and quantitative label-free microscopy-based approach to study pro-fibrotic signalling in ex vivo human precision-cut lung slices

par Khan, Muzamil Majid, Poeckel, Daniel, Halavatyi, Aliaksandr, Zukowska-Kasprzyk, Joanna, Stein, Frank, Vappiani, Johanna, Sevin, Daniel C., Tischer, Christian, Zinn, Nico, Eley, Jessica D., Gudmann, Natasja Stæhr, Muley, Thomas, Winter, Hauke, Fisher, Andrew J., Nanthakumar, Carmel B., Bergamini, Giovanna, Pepperkok, Rainer
Publié dans Eur Respir J (2021)

Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS

par Schenck Eidam, Hilary, Russell, John, Raha, Kaushik, DeMartino, Michael, Qin, Donghui, Guan, Huiping Amy, Zhang, Zhiliu, Zhen, Gong, Yu, Haiyu, Wu, Chengde, Pan, Yan, Joberty, Gerard, Zinn, Nico, Laquerre, Sylvie, Robinson, Sharon, White, Angela, Giddings, Amanda, Mohammadi, Ehsan, Greenwood-Van Meerveld, Beverly, Oliff, Allen, Kumar, Sanjay, Cheung, Mui
Publié dans ACS Med Chem Lett (2018)

Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis

par Savitski, Mikhail M., Zinn, Nico, Faelth-Savitski, Maria, Poeckel, Daniel, Gade, Stephan, Becher, Isabelle, Muelbaier, Marcel, Wagner, Anne J., Strohmer, Katrin, Werner, Thilo, Melchert, Stephanie, Petretich, Massimo, Rutkowska, Anna, Vappiani, Johanna, Franken, Holger, Steidel, Michael, Sweetman, Gavain M., Gilan, Omer, Lam, Enid Y.N., Dawson, Mark A., Prinjha, Rab K., Grandi, Paola, Bergamini, Giovanna, Bantscheff, Marcus
Publié dans Cell (2018)

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

par Woodcock, Hannah V., Eley, Jessica D., Guillotin, Delphine, Platé, Manuela, Nanthakumar, Carmel B., Martufi, Matteo, Peace, Simon, Joberty, Gerard, Poeckel, Daniel, Good, Robert B., Taylor, Adam R., Zinn, Nico, Redding, Matthew, Forty, Ellen J., Hynds, Robert E., Swanton, Charles, Karsdal, Morten, Maher, Toby M., Bergamini, Giovanna, Marshall, Richard P., Blanchard, Andy D., Mercer, Paul F., Chambers, Rachel C.
Publié dans Nat Commun (2019)

Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2

par Mares, Alina, Miah, Afjal H., Smith, Ian E. D., Rackham, Mark, Thawani, Aditya R., Cryan, Jenni, Haile, Pamela A., Votta, Bartholomew J., Beal, Allison M., Capriotti, Carol, Reilly, Michael A., Fisher, Don T., Zinn, Nico, Bantscheff, Marcus, MacDonald, Thomas T., Vossenkamper, Anna, Dace, Phoebe, Churcher, Ian, Benowitz, Andrew B., Watt, Gillian, Denyer, Jane, Scott-Stevens, Paul, Harling, John D.
Publié dans Commun Biol (2020)

Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

par Woodcock, Hannah V., Eley, Jessica D., Guillotin, Delphine, Platé, Manuela, Nanthakumar, Carmel B., Martufi, Matteo, Peace, Simon, Joberty, Gerard, Poeckel, Daniel, Good, Robert B., Taylor, Adam R., Zinn, Nico, Redding, Matthew, Forty, Ellen J., Hynds, Robert E., Swanton, Charles, Karsdal, Morten, Maher, Toby M., Fisher, Andrew, Bergamini, Giovanna, Marshall, Richard P., Blanchard, Andy D., Mercer, Paul F., Chambers, Rachel C.
Publié dans Nat Commun (2020)

Catalytic in vivo protein knockdown by small-molecule PROTACs

par Bondeson, Daniel P, Mares, Alina, Smith, Ian E D, Ko, Eunhwa, Campos, Sebastien, Miah, Afjal H, Mulholland, Katie E, Routly, Natasha, Buckley, Dennis L, Gustafson, Jeffrey L, Zinn, Nico, Grandi, Paola, Shimamura, Satoko, Bergamini, Giovanna, Faelth-Savitski, Maria, Bantscheff, Marcus, Cox, Carly, Gordon, Deborah A, Willard, Ryan R, Flanagan, John J, Casillas, Linda N, Votta, Bartholomew J, den Besten, Willem, Famm, Kristoffer, Kruidenier, Laurens, Carter, Paul S, Harling, John D, Churcher, Ian, Crews, Craig M
Publié dans Nat Chem Biol (2015)