Biophysical Studies on Interactions and Assembly of Full-size E3 Ubiquitin Ligase: SUPPRESSOR OF CYTOKINE SIGNALING 2 (SOCS2)-ELONGIN BC-CULLIN 5-RING BOX PROTEIN 2 (RBX2)

por Bulatov, Emil, Martin, Esther M., Chatterjee, Sneha, Knebel, Axel, Shimamura, Satoko, Konijnenberg, Albert, Johnson, Clare, Zinn, Nico, Grandi, Paola, Sobott, Frank, Ciulli, Alessio
Publicado en J Biol Chem (2015)

Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons

por Ramsden, Nigel, Perrin, Jessica, Ren, Zhao, Lee, Byoung Dae, Zinn, Nico, Dawson, Valina L., Tam, Danny, Bova, Michael, Delling, Manja, Drewes, Gerard, Bantscheff, Marcus, Bard, Frederique, Dawson, Ted M., Hopf, Carsten
Publicado 2011

Systematic analysis of protein turnover in primary cells

por Mathieson, Toby, Franken, Holger, Kosinski, Jan, Kurzawa, Nils, Zinn, Nico, Sweetman, Gavain, Poeckel, Daniel, Ratnu, Vikram S., Schramm, Maike, Becher, Isabelle, Steidel, Michael, Noh, Kyung-Min, Bergamini, Giovanna, Beck, Martin, Bantscheff, Marcus, Savitski, Mikhail M.
Publicado en Nat Commun (2018)

CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model

por Cansfield, Andrew D., Ladduwahetty, Tammy, Sunose, Mihiro, Ellard, Katie, Lynch, Rosemary, Newton, Anthea L., Lewis, Ann, Bennett, Gavin, Zinn, Nico, Thomson, Douglas W., Rüger, Anne J., Feutrill, John T., Rausch, Oliver, Watt, Alan P., Bergamini, Giovanna
Publicado en ACS Med Chem Lett (2016)

Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor

por Thomson, Douglas W., Poeckel, Daniel, Zinn, Nico, Rau, Christina, Strohmer, Katrin, Wagner, Anne J., Graves, Alan P., Perrin, Jessica, Bantscheff, Marcus, Duempelfeld, Birgit, Kasparcova, Viera, Ramanjulu, Joshi M., Pesiridis, G. Scott, Muelbaier, Marcel, Bergamini, Giovanna
Publicado en ACS Med Chem Lett (2019)

An integrated multiomic and quantitative label-free microscopy-based approach to study pro-fibrotic signalling in ex vivo human precision-cut lung slices

por Khan, Muzamil Majid, Poeckel, Daniel, Halavatyi, Aliaksandr, Zukowska-Kasprzyk, Joanna, Stein, Frank, Vappiani, Johanna, Sevin, Daniel C., Tischer, Christian, Zinn, Nico, Eley, Jessica D., Gudmann, Natasja Stæhr, Muley, Thomas, Winter, Hauke, Fisher, Andrew J., Nanthakumar, Carmel B., Bergamini, Giovanna, Pepperkok, Rainer
Publicado en Eur Respir J (2021)

Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS

por Schenck Eidam, Hilary, Russell, John, Raha, Kaushik, DeMartino, Michael, Qin, Donghui, Guan, Huiping Amy, Zhang, Zhiliu, Zhen, Gong, Yu, Haiyu, Wu, Chengde, Pan, Yan, Joberty, Gerard, Zinn, Nico, Laquerre, Sylvie, Robinson, Sharon, White, Angela, Giddings, Amanda, Mohammadi, Ehsan, Greenwood-Van Meerveld, Beverly, Oliff, Allen, Kumar, Sanjay, Cheung, Mui
Publicado en ACS Med Chem Lett (2018)

Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis

por Savitski, Mikhail M., Zinn, Nico, Faelth-Savitski, Maria, Poeckel, Daniel, Gade, Stephan, Becher, Isabelle, Muelbaier, Marcel, Wagner, Anne J., Strohmer, Katrin, Werner, Thilo, Melchert, Stephanie, Petretich, Massimo, Rutkowska, Anna, Vappiani, Johanna, Franken, Holger, Steidel, Michael, Sweetman, Gavain M., Gilan, Omer, Lam, Enid Y.N., Dawson, Mark A., Prinjha, Rab K., Grandi, Paola, Bergamini, Giovanna, Bantscheff, Marcus
Publicado en Cell (2018)

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

por Woodcock, Hannah V., Eley, Jessica D., Guillotin, Delphine, Platé, Manuela, Nanthakumar, Carmel B., Martufi, Matteo, Peace, Simon, Joberty, Gerard, Poeckel, Daniel, Good, Robert B., Taylor, Adam R., Zinn, Nico, Redding, Matthew, Forty, Ellen J., Hynds, Robert E., Swanton, Charles, Karsdal, Morten, Maher, Toby M., Bergamini, Giovanna, Marshall, Richard P., Blanchard, Andy D., Mercer, Paul F., Chambers, Rachel C.
Publicado en Nat Commun (2019)

Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2

por Mares, Alina, Miah, Afjal H., Smith, Ian E. D., Rackham, Mark, Thawani, Aditya R., Cryan, Jenni, Haile, Pamela A., Votta, Bartholomew J., Beal, Allison M., Capriotti, Carol, Reilly, Michael A., Fisher, Don T., Zinn, Nico, Bantscheff, Marcus, MacDonald, Thomas T., Vossenkamper, Anna, Dace, Phoebe, Churcher, Ian, Benowitz, Andrew B., Watt, Gillian, Denyer, Jane, Scott-Stevens, Paul, Harling, John D.
Publicado en Commun Biol (2020)

Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

por Woodcock, Hannah V., Eley, Jessica D., Guillotin, Delphine, Platé, Manuela, Nanthakumar, Carmel B., Martufi, Matteo, Peace, Simon, Joberty, Gerard, Poeckel, Daniel, Good, Robert B., Taylor, Adam R., Zinn, Nico, Redding, Matthew, Forty, Ellen J., Hynds, Robert E., Swanton, Charles, Karsdal, Morten, Maher, Toby M., Fisher, Andrew, Bergamini, Giovanna, Marshall, Richard P., Blanchard, Andy D., Mercer, Paul F., Chambers, Rachel C.
Publicado en Nat Commun (2020)

Catalytic in vivo protein knockdown by small-molecule PROTACs

por Bondeson, Daniel P, Mares, Alina, Smith, Ian E D, Ko, Eunhwa, Campos, Sebastien, Miah, Afjal H, Mulholland, Katie E, Routly, Natasha, Buckley, Dennis L, Gustafson, Jeffrey L, Zinn, Nico, Grandi, Paola, Shimamura, Satoko, Bergamini, Giovanna, Faelth-Savitski, Maria, Bantscheff, Marcus, Cox, Carly, Gordon, Deborah A, Willard, Ryan R, Flanagan, John J, Casillas, Linda N, Votta, Bartholomew J, den Besten, Willem, Famm, Kristoffer, Kruidenier, Laurens, Carter, Paul S, Harling, John D, Churcher, Ian, Crews, Craig M
Publicado en Nat Chem Biol (2015)