Machine learning optimized polygenic scores for blood cell traits identify sex-specific trajectories and genetic correlations with disease

por Yu Xu, Dragana Vuckovic, Scott C. Ritchie, Parsa Akbari, Tao Jiang, Jason Grealey, Adam S. Butterworth, Willem H. Ouwehand, David J. Roberts, Emanuele Di Angelantonio, John Danesh, Nicole Soranzo, Michael Inouye
Publicado 2022-01-01

Single nucleotide variants in the protein C pathway and mortality in dialysis patients.

por Gürbey Ocak, Christiane Drechsler, Carla Y Vossen, Hans L Vos, Frits R Rosendaal, Pieter H Reitsma, Michael M Hoffmann, Winfried März, Willem H Ouwehand, Raymond T Krediet, Elisabeth W Boeschoten, Friedo W Dekker, Christoph Wanner, Marion Verduijn
Publicado 2014-01-01

SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume.

por Siying Zou, Alexandra M Teixeira, Myrto Kostadima, William J Astle, Aparna Radhakrishnan, Lukas Mikolaj Simon, Lucy Truman, Jennifer S Fang, John Hwa, Ping-Xia Zhang, Pim van der Harst, Paul F Bray, Willem H Ouwehand, Mattia Frontini, Diane S Krause
Publicado 2017-01-01

Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution.

por Pawandeep Dhami, Peter Saffrey, Alexander W Bruce, Shane C Dillon, Kelly Chiang, Nicolas Bonhoure, Christoph M Koch, Jackie Bye, Keith James, Nicola S Foad, Peter Ellis, Nicholas A Watkins, Willem H Ouwehand, Cordelia Langford, Robert M Andrews, Ian Dunham, David Vetrie
Publicado 2010-08-01

Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression.

por Nicolas Greliche, Tanja Zeller, Philipp S Wild, Maxime Rotival, Arne Schillert, Andreas Ziegler, Cardiogenics Consortium, Panos Deloukas, Jeanette Erdmann, Christian Hengstenberg, Willem H Ouwehand, Nilesh J Samani, Heribert Schunkert, Thomas Munzel, Karl J Lackner, François Cambien, Alison H Goodall, Laurence Tiret, Stefan Blankenberg, David-Alexandre Trégouët
Publicado 2012-01-01

Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis.

por Stephanie Maiwald, Suthesh Sivapalaratnam, Mahdi M Motazacker, Julian C van Capelleveen, Ilze Bot, Saskia C de Jager, Miranda van Eck, Jennifer Jolley, Johan Kuiper, Jonathon Stephens, Cornelius A Albers, C Ruben Vosmeer, Heleen Kruize, Daan P Geerke, Allard C van der Wal, Chris M van der Loos, John J P Kastelein, Mieke D Trip, Willem H Ouwehand, Geesje M Dallinga-Thie, G Kees Hovingh
Publicado 2014-01-01