Machine learning optimized polygenic scores for blood cell traits identify sex-specific trajectories and genetic correlations with disease

Por Yu Xu, Dragana Vuckovic, Scott C. Ritchie, Parsa Akbari, Tao Jiang, Jason Grealey, Adam S. Butterworth, Willem H. Ouwehand, David J. Roberts, Emanuele Di Angelantonio, John Danesh, Nicole Soranzo, Michael Inouye
Publicado em 2022-01-01

Risk factors and prediction models for incident heart failure with reduced and preserved ejection fraction

Por Liam Gaziano, Kelly Cho, Luc Djousse, Petra Schubert, Ashley Galloway, Yuk‐Lam Ho, Katherine Kurgansky, David R. Gagnon, John P. Russo, Emanuele Di Angelantonio, Angela M. Wood, John Danesh, John Michael Gaziano, Adam S. Butterworth, Peter W.F. Wilson, Jacob Joseph
Publicado em 2021-12-01

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases.

Por Ricardo C Ferreira, Daniel F Freitag, Antony J Cutler, Joanna M M Howson, Daniel B Rainbow, Deborah J Smyth, Stephen Kaptoge, Pamela Clarke, Charlotte Boreham, Richard M Coulson, Marcin L Pekalski, Wei-Min Chen, Suna Onengut-Gumuscu, Stephen S Rich, Adam S Butterworth, Anders Malarstig, John Danesh, John A Todd
Publicado em 2013-04-01