Biosimilars entering the clinic without animal studies: A paradigm shift in the European Union

Por van Aerts, Leon AGJM, De Smet, Karen, Reichmann, Gabriele, van der Laan, Jan Willem, Schneider, Christian K
Publicado no MAbs (2014)

Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells

Por ter Braak, Bas, Wink, Steven, Koedoot, Esmee, Pont, Chantal, Siezen, Christine, van der Laan, Jan Willem, van de Water, Bob
Publicado no Breast Cancer Res (2015)

Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production

Por ter Braak, Bas, Siezen, Christine L., Lee, Joo S., Rao, Pooja, Voorhoeve, Charlotte, Ruppin, Eytan, van der Laan, Jan Willem, van de Water, Bob
Publicado no Breast Cancer Res (2017)

Challenges and opportunities for the future of monoclonal antibody development: Improving safety assessment and reducing animal use

Por Sewell, Fiona, Chapman, Kathryn, Couch, Jessica, Dempster, Maggie, Heidel, Shawn, Loberg, Lise, Maier, Curtis, Maclachlan, Timothy K., Todd, Marque, van der Laan, Jan Willem
Publicado no MAbs (2017)

Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53(R270H/+)WAPCre mouse model

Por ter Braak, Bas, Siezen, Christine, Speksnijder, Ewoud N, Koedoot, Esmee, van Steeg, Harry, Salvatori, Daniela CF, van de Water, Bob, van der Laan, Jan Willem
Publicado no Breast Cancer Res (2015)

Statins accelerate the onset of collagen type II-induced arthritis in mice

Por Vandebriel, Rob J, De Jong, Hilda JI, Gremmer, Eric R, Klungel, Olaf H, Tervaert, Jan-Willem Cohen, Slob, Wout, Van Der Laan, Jan Willem, Van Loveren, Henk
Publicado em 2012

Prediction of the Carcinogenic Potential of Human Pharmaceuticals Using Repeated Dose Toxicity Data and Their Pharmacological Properties

Por van der Laan, Jan Willem, Buitenhuis, Wenny H. W., Wagenaar, Laura, Soffers, Ans E. M. F., van Someren, Eugene P., Krul, Cyrille A. M., Woutersen, Ruud A.
Publicado no Front Med (Lausanne) (2016)

Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence

Por Bronsveld, Heleen K, ter Braak, Bas, Karlstad, Øystein, Vestergaard, Peter, Starup-Linde, Jakob, Bazelier, Marloes T, De Bruin, Marie L, de Boer, Anthonius, Siezen, Christine L E, van de Water, Bob, van der Laan, Jan Willem, Schmidt, Marjanka K
Publicado no Breast Cancer Res (2015)