Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors

Yazar: Seganish, W. Michael, Fischmann, Thierry O., Sherborne, Brad, Matasi, Julius, Lavey, Brian, McElroy, William T., Tulshian, Deen, Tata, James, Sondey, Christopher, Garlisi, Charles G., Devito, Kristine, Fossetta, James, Lundell, Daniel, Niu, Xiaoda
Yayımlandı ACS Med Chem Lett (2015)

Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors

Yazar: McLeod, Robbie L, Parra, Leonard E, Mutter, Jennifer C, Erickson, Christine H, Carey, Galen J, Tulshian, Deen B, Fawzi, Ahmad B, Smith-Torhan, April, Egan, Robert W, Cuss, Francis M, Hey, John A
Baskı/Yayın Bilgisi 2001

Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation

Yazar: McElroy, William T., Tan, Zheng, Ho, Ginny, Paliwal, Sunil, Li, Guoqing, Seganish, W. Michael, Tulshian, Deen, Tata, James, Fischmann, Thierry O., Sondey, Christopher, Bian, Hong, Bober, Loretta, Jackson, James, Garlisi, Charles G., Devito, Kristine, Fossetta, James, Lundell, Daniel, Niu, Xiaoda
Yayımlandı ACS Med Chem Lett (2015)

Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical mod...

Yazar: McLeod, Robbie L., Tulshian, Deen B., Bolser, Donald C., Varty, Geoffrey B., Baptista, Marco, Fernandez, Xiomara, Parra, Leonard E., Zimmer, Jennifer C., Erickson, Christine H., Ho, Ginny D., Jia, Yanlin, Ng, Fay W., Korfmacher, Walter, Xu, Xiaoying, Veals, John, Smith-Torhan, April, Wainhaus, Samuel, Fawzi, Ahmad B., Austin, Theodore M., van Heek, Margaret, Hey, John A.
Baskı/Yayın Bilgisi 2009