Making sense of the kinetics of reactions of unstable modifiers with enzymes.

Por Topham, C M
Publicado em 1992

Chemical modification of enzymes: reaction with an unstable inhibitor.

Por Topham, C M
Publicado em 1985

Computer simulations of the kinetics of irreversible enzyme inhibition by an unstable inhibitor.

Por Topham, C M
Publicado em 1986

Alternative methods for the determination of rate constants describing enzyme inactivation by an unstable inhibitor.

Por Topham, C M
Publicado em 1987

In defence of the general validity of the Cha method of deriving rate equations. The importance of explicit recognition of the thermodynamic box in enzyme kinetics.

Por Topham, C M, Brocklehurst, K
Publicado em 1992

Kinetic parameters of the acyl-enzyme mechanism and conditions for quasi-equilibrium and for optimal catalytic characteristics.

Por Brocklehurst, K, Topham, C M
Publicado em 1990

Some classical errors in the kinetic analysis of enzyme reactions.

Por Brocklehurst, K, Topham, C M
Publicado em 1993

The chemical mechanism of sheep liver 6-phosphogluconate dehydrogenase. A Schiff-base intermediate is not involved.

Por Topham, C M, Dalziel, K
Publicado em 1986

Ionization characteristics of the Cys-25/His-159 interactive system and of the modulatory group of papain: resolution of ambiguity by electronic perturbation of the quasi-2-mercapt...

Por Mellor, G W, Thomas, E W, Topham, C M, Brocklehurst, K
Publicado em 1993

A re-appraisal of the structural basis of stereochemical recognition in papain. Insensitivity of binding-site-catalytic-site signalling to P2-chirality in a time-dependent inhibiti...

Por Templeton, W, Kowlessur, D, Thomas, E W, Topham, C M, Brocklehurst, K
Publicado em 1990

Dependence of the P2-S2 stereochemical selectivity of papain on the nature of the catalytic-site chemistry. Quantification of selectivity in the catalysed hydrolysis of the enantio...

Por Kowlessur, D, Thomas, E W, Topham, C M, Templeton, W, Brocklehurst, K
Publicado em 1990

A general kinetic approach to investigation of active-site availability in macromolecular catalysts.

Por Resmini, M, Gul, S, Carter, S, Sonkaria, S, Topham, C M, Gallacher, G, Brocklehurst, K
Publicado em 2000

Randomised trial of epirubicin alone versus 5-fluorouracil, epirubicin and mitomycin C in locally advanced and metastatic carcinoma of the pancreas.

Por Topham, C., Glees, J., Rawson, N. S., Woods, E. M., Coombes, R. C.
Publicado em 1991

Identification of signalling and non-signalling binding contributions to enzyme reactivity. Alternative combinations of binding interactions provide for change in transition-state...

Por Kowlessur, D, Topham, C M, Thomas, E W, O'Driscoll, M, Templeton, W, Brocklehurst, K
Publicado em 1989

The interplay of electrostatic fields and binding interactions determining catalytic-site reactivity in actinidin. A possible origin of differences in the behaviour of actinidin an...

Por Kowlessur, D, O'Driscoll, M, Topham, C M, Templeton, W, Thomas, E W, Brocklehurst, K
Publicado em 1989

A phase I and II study of 2-weekly irinotecan with capecitabine in advanced gastroesophageal adenocarcinoma

Por Burge, M E, Smith, D, Topham, C, Jackson, D P, Anthoney, D A, Halstead, F, Seymour, M T
Publicado em 2006

Structure of chymopapain M the late-eluted chymopapain deduced by comparative modelling techniques and active-centre characteristics determined by pH-dependent kinetics of catalysi...

Por Thomas, M P, Topham, C M, Kowlessur, D, Mellor, G W, Thomas, E W, Whitford, D, Brocklehurst, K
Publicado em 1994

A polyclonal antibody preparation with Michaelian catalytic properties.

Por Gallacher, G, Jackson, C S, Searcey, M, Badman, G T, Goel, R, Topham, C M, Mellor, G W, Brocklehurst, K
Publicado em 1991

Exploration of subsite binding specificity of human cathepsin D through kinetics and rule-based molecular modeling.

Por Scarborough, P. E., Guruprasad, K., Topham, C., Richo, G. R., Conner, G. E., Blundell, T. L., Dunn, B. M.
Publicado em 1993

Preoperative downstaging chemoradiation with concurrent irinotecan and capecitabine in MRI-defined locally advanced rectal cancer: a phase I trial (NWCOG-2)

Por Gollins, S W, Myint, S, Susnerwala, S, Haylock, B, Wise, M, Topham, C, Samuel, L, Swindell, R, Morris, J, Mason, L, Levine, E
Publicado em 2009