A novel anti-inflammatory natural product from Sphaeranthus indicus inhibits expression of VCAM1 and ICAM1, and slows atherosclerosis progression independent of lipid changes

Por Srivastava, Rai Ajit K., Mistry, Sapna, Sharma, Somesh
Publicado no Nutr Metab (Lond) (2015)

Comparative Evaluation of Gemcabene and Peroxisome Proliferator–Activated Receptor Ligands in Transcriptional Assays of Peroxisome Proliferator–Activated Receptors: Implication for...

Por Bisgaier, Charles L., Oniciu, Daniela C., Srivastava, Rai Ajit K.
Publicado no J Cardiovasc Pharmacol (2018)

Gemcabene, a first-in-class lipid-lowering agent in late-stage development, down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism

Por Srivastava, Rai Ajit K., Cornicelli, Joseph A., Markham, Bruce, Bisgaier, Charles L.
Publicado no Mol Cell Biochem (2018)

AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases: Thematic Review Series: New Li...

Por Srivastava, Rai Ajit K., Pinkosky, Stephen L., Filippov, Sergey, Hanselman, Jeffrey C., Cramer, Clay T., Newton, Roger S.
Publicado em 2012

ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK

Por Filippov, Sergey, Pinkosky, Stephen L., Lister, Richard J., Pawloski, Catherine, Hanselman, Jeffrey C., Cramer, Clay T., Srivastava, Rai Ajit K., Hurley, Timothy R., Bradshaw, Cheryl D., Spahr, Mark A., Newton, Roger S.
Publicado em 2013

AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism

Por Pinkosky, Stephen L., Filippov, Sergey, Srivastava, Rai Ajit K., Hanselman, Jeffrey C., Bradshaw, Cheryl D., Hurley, Timothy R., Cramer, Clay T., Spahr, Mark A., Brant, Ashley F., Houghton, Jacob L., Baker, Chris, Naples, Mark, Adeli, Khosrow, Newton, Roger S.
Publicado em 2013