ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK

Por Filippov, Sergey, Pinkosky, Stephen L., Lister, Richard J., Pawloski, Catherine, Hanselman, Jeffrey C., Cramer, Clay T., Srivastava, Rai Ajit K., Hurley, Timothy R., Bradshaw, Cheryl D., Spahr, Mark A., Newton, Roger S.
Publicado em 2013

AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism

Por Pinkosky, Stephen L., Filippov, Sergey, Srivastava, Rai Ajit K., Hanselman, Jeffrey C., Bradshaw, Cheryl D., Hurley, Timothy R., Cramer, Clay T., Spahr, Mark A., Brant, Ashley F., Houghton, Jacob L., Baker, Chris, Naples, Mark, Adeli, Khosrow, Newton, Roger S.
Publicado em 2013