The Lysosome at the intersection of cellular growth and destruction.

by Shin, Hijai R., Zoncu, Roberto
Published in Dev Cell (2020)

Covalent Targeting of the Vacuolar H(+)-ATPase Activates Autophagy Via mTORC1 Inhibition

by Yik-Sham Chung, Clive, Shin, Hijai R., Berdan, Charles A., Ford, Breanna, Ward, Carl C., Olzmann, James A., Zoncu, Roberto, Nomura, Daniel K.
Published in Nat Chem Biol (2019)

ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signaling in Niemann-Pick type C

by Lim, Chun-Yan, Davis, Oliver B., Shin, Hijai R., Zhang, Justin, Berdan, Charles A., Jiang, Xuntian, Counihan, Jessica L., Ory, Daniel S., Nomura, Daniel K., Zoncu, Roberto
Published in Nat Cell Biol (2019)

Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy

by Yu, Young Suk, Shin, Hijai R., Kim, Dongha, Baek, Seon Ah, Choi, Seon Ah, Ahn, Hyejin, Shamim, Amen, Kim, Jeonghwan, Kim, Ik Soo, Kim, Kyeong Kyu, Won, Kyoung-Jae, Baek, Sung Hee
Published in Nat Commun (2020)

The hypothalamic–pituitary–gonadal axis controls muscle stem cell senescence through autophagosome clearance

by Kim, Ji‐Hoon, Park, Inkuk, Shin, Hijai R., Rhee, Joonwoo, Seo, Ji‐Yun, Jo, Young‐Woo, Yoo, Kyusang, Hann, Sang‐Hyeon, Kang, Jong‐Seol, Park, Jieon, Kim, Ye Lynne, Moon, Ju‐Yeon, Choi, Man Ho, Kong, Young‐Yun
Published in J Cachexia Sarcopenia Muscle (2020)