Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function.

por Liu, F, Roth, R A
Publicado 1995

A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies.

por Zhang, B, Roth, R A
Publicado 1991

Inhibition of insulin degradation by hepatoma cells after microinjection of monoclonal antibodies to a specific cytosolic protease.

por Shii, K, Roth, R A
Publicado 1986

Identification of serines-967/968 in the juxtamembrane region of the insulin receptor as insulin-stimulated phosphorylation sites.

por Liu, F, Roth, R A
Publicado 1994

Alteration of monocrotaline pyrrole-induced cardiopulmonary effects in rats by hydrallazine, dexamethasone or sulphinpyrazone.

por Hilliker, K. S., Roth, R. A.
Publicado 1984

Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin.

por Morgan, D O, Roth, R A
Publicado 1987

An unusual active site identified in a family of zinc metalloendopeptidases.

por Becker, A B, Roth, R A
Publicado 1992

Identification of glutamate-169 as the third zinc-binding residue in proteinase III, a member of the family of insulin-degrading enzymes.

por Becker, A B, Roth, R A
Publicado 1993

The effects of monocrotaline pyrrole on cultured bovine pulmonary artery endothelial and smooth muscle cells.

por Reindel, J. F., Roth, R. A.
Publicado 1991

Monocrotaline pyrrole-induced changes in angiotensin-converting enzyme activity of cultured pulmonary artery endothelial cells.

por Hoorn, C. M., Roth, R. A.
Publicado 1993

Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase.

por Kohn, A D, Kovacina, K S, Roth, R A
Publicado 1995

Characterization of acute 4,4'-methylene dianiline hepatotoxicity in the rat.

por Bailie, M B, Mullaney, T P, Roth, R A
Publicado 1993

Activated neutrophils injure the isolated, perfused rat liver by an oxygen radical-dependent mechanism.

por Dahm, L. J., Schultze, A. E., Roth, R. A.
Publicado 1991

Activation of protein kinase B/cAkt in hepatocytes is sufficient for the induction of expression of the gene encoding glucokinase.

por Iynedjian, P B, Roth, R A, Fleischmann, M, Gjinovci, A
Publicado 2000

Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase.

por Morgan, D O, Ho, L, Korn, L J, Roth, R A
Publicado 1986

Dual regulation of glycogen metabolism by insulin and insulin-like growth factors in human hepatoma cells (HEP-G2). Analysis with an anti-receptor monoclonal antibody.

por Verspohl, E J, Roth, R A, Vigneri, R, Goldfine, I D
Publicado 1984

Inhibition of insulin receptor phosphorylation by peptides derived from major histocompatibility complex class I antigens.

por Hansen, T, Stagsted, J, Pedersen, L, Roth, R A, Goldstein, A, Olsson, L
Publicado 1989

Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity.

por Bollag, G E, Roth, R A, Beaudoin, J, Mochly-Rosen, D, Koshland, D E
Publicado 1986

Neutrophil function after exposure to polychlorinated biphenyls in vitro.

por Ganey, P E, Sirois, J E, Denison, M, Robinson, J P, Roth, R A
Publicado 1993

Molecular basis of the activation of the tumorigenic potential of Gag-insulin receptor chimeras.

por Poon, B, Dixon, D, Ellis, L, Roth, R A, Rutter, W J, Wang, L H
Publicado 1991