Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)

par Li, Jun, Kennedy, Lawrence J., Wang, Haixia, Li, James J., Walker, Steven J., Hong, Zhenqiu, O’Connor, Stephen P., Nayeem, Akbar, Camac, Daniel M., Morin, Paul E., Sheriff, Steven, Wang, Mengmeng, Harper, Timothy, Golla, Rajasree, Seethala, Ramakrishna, Harrity, Thomas, Ponticiello, Randolph P., Morgan, Nathan N., Taylor, Joseph R., Zebo, Rachel, Gordon, David A., Robl, Jeffrey A.
Publié 2014

Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)

par Li, Jun, Kennedy, Lawrence J., Walker, Steven J., Wang, Haixia, Li, James J., Hong, Zhenqiu, O’Connor, Stephen P., Ye, Xiang-yang, Chen, Stephanie, Wu, Shung, Yoon, David S., Nayeem, Akbar, Camac, Daniel M., Ramamurthy, Vidhyashankar, Morin, Paul E., Sheriff, Steven, Wang, Mengmeng, Harper, Timothy W., Golla, Rajasree, Seethala, Ramakrishna, Harrity, Thomas, Ponticiello, Randolph P., Morgan, Nathan N., Taylor, Joseph R., Zebo, Rachel, Maxwell, Brad, Moulin, Frederick, Gordon, David A., Robl, Jeffrey A.
Publié dans ACS Med Chem Lett (2018)