Antibodies selected from combinatorial libraries block a tumor antigen that plays a key role in immunomodulation

by McWhirter, John R., Kretz-Rommel, Anke, Saven, Alan, Maruyama, Toshiaki, Potter, Kathleen N., Mockridge, C. Ian, Ravey, E. Prenn, Qin, Fenghua, Bowdish, Katherine S.
Published 2006

FcγRII (CD32) modulates antibody clearance in NOD SCID mice leading to impaired antibody-mediated tumor cell deletion

by Oldham, Robert J, Mockridge, C Ian, James, Sonya, Duriez, Patrick J, Chan, H T Claude, Cox, Kerry L, Pitic, Vicentiu A, Glennie, Martin J, Cragg, Mark S
Published in J Immunother Cancer (2020)

Augmentation of CD134 (OX40)-dependent NK anti-tumour activity is dependent on antibody cross-linking

by Turaj, Anna H., Cox, Kerry L., Penfold, Christine A., French, Ruth R., Mockridge, C. Ian, Willoughby, Jane E., Tutt, Alison L., Griffiths, Jordana, Johnson, Peter W. M., Glennie, Martin J., Levy, Ronald, Cragg, Mark S., Lim, Sean H.
Published in Sci Rep (2018)

Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity

by Yu, Xiaojie, Chan, H.T. Claude, Fisher, Hayden, Penfold, Christine A., Kim, Jinny, Inzhelevskaya, Tatyana, Mockridge, C. Ian, French, Ruth R., Duriez, Patrick J., Douglas, Leon R., English, Vikki, Verbeek, J. Sjef, White, Ann L., Tews, Ivo, Glennie, Martin J., Cragg, Mark S.
Published in Cancer Cell (2020)

TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity

by Yu, Xiaojie, James, Sonya, Felce, James H., Kellermayer, Blanka, Johnston, David A., Chan, H. T. Claude, Penfold, Christine A., Kim, Jinny, Inzhelevskaya, Tatyana, Mockridge, C. Ian, Watanabe, Yasunori, Crispin, Max, French, Ruth R., Duriez, Patrick J., Douglas, Leon R., Glennie, Martin J., Cragg, Mark S.
Published in Commun Biol (2021)

Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies

by Yu, Xiaojie, Chan, H.T. Claude, Orr, Christian M., Dadas, Osman, Booth, Steven G., Dahal, Lekh N., Penfold, Christine A., O'Brien, Lyn, Mockridge, C. Ian, French, Ruth R., Duriez, Patrick, Douglas, Leon R., Pearson, Arwen R., Cragg, Mark S., Tews, Ivo, Glennie, Martin J., White, Ann L.
Published in Cancer Cell (2018)

LILRB3 (ILT5) is a myeloid cell checkpoint that elicits profound immunomodulation

by Yeboah, Muchaala, Papagregoriou, Charys, Jones, Des C., Chan, H.T. Claude, Hu, Guangan, McPartlan, Justine S., Schiött, Torbjörn, Mattson, Ulrika, Mockridge, C. Ian, Tornberg, Ulla-Carin, Hambe, Björn, Ljungars, Anne, Mattsson, Mikael, Tews, Ivo, Glennie, Martin J., Thirdborough, Stephen M., Trowsdale, John, Frendeus, Björn, Chen, Jianzhu, Cragg, Mark S., Roghanian, Ali
Published in JCI Insight (2020)

Conformation of the Human Immunoglobulin G2 Hinge Imparts Superagonistic Properties to Immunostimulatory Anticancer Antibodies

by White, Ann L., Chan, H.T. Claude, French, Ruth R., Willoughby, Jane, Mockridge, C. Ian, Roghanian, Ali, Penfold, Christine A., Booth, Steven G., Dodhy, Ali, Polak, Marta E., Potter, Elizabeth A., Ardern-Jones, Michael R., Verbeek, J. Sjef, Johnson, Peter W.M., Al-Shamkhani, Aymen, Cragg, Mark S., Beers, Stephen A., Glennie, Martin J.
Published in Cancer Cell (2015)

Domain binding and isotype dictate the activity of anti-human OX40 antibodies

by Griffiths, Jordana, Hussain, Khiyam, Smith, Hannah L, Sanders, Theodore, Cox, Kerry L, Semmrich, Monika, Mårtensson, Linda, Kim, Jinny, Inzhelevskaya, Tatyana, Penfold, Chris A, Tutt, Alison L, Mockridge, C Ian, Chan, HT Claude, English, Vikki, French, Ruth F, Teige, Ingrid, Al-Shamkhani, Aymen, Glennie, Martin J, Frendeus, Bjorn L, Willoughby, Jane E, Cragg, Mark S
Published in J Immunother Cancer (2020)