Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease

Por Van Broeck, B, Chen, J-M, Tréton, G, Desmidt, M, Hopf, C, Ramsden, N, Karran, E, Mercken, M, Rowley, A
Publicado em 2011

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.

Por Biernat, J, Mandelkow, E M, Schröter, C, Lichtenberg-Kraag, B, Steiner, B, Berling, B, Meyer, H, Mercken, M, Vandermeeren, A, Goedert, M
Publicado em 1992

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

Por Chapuis, J, Hansmannel, F, Gistelinck, M, Mounier, A, Van Cauwenberghe, C, Kolen, K V, Geller, F, Sottejeau, Y, Harold, D, Dourlen, P, Grenier-Boley, B, Kamatani, Y, Delepine, B, Demiautte, F, Zelenika, D, Zommer, N, Hamdane, M, Bellenguez, C, Dartigues, J-F, Hauw, J-J, Letronne, F, Ayral, A-M, Sleegers, K, Schellens, A, Broeck, L V, Engelborghs, S, De Deyn, P P, Vandenberghe, R, O'Donovan, M, Owen, M, Epelbaum, J, Mercken, M, Karran, E, Bantscheff, M, Drewes, G, Joberty, G, Campion, D, Octave, J-N, Berr, C, Lathrop, M, Callaerts, P, Mann, D, Williams, J, Buée, L, Dewachter, I, Van Broeckhoven, C, Amouyel, P, Moechars, D, Dermaut, B, Lambert, J-C
Publicado em 2013