API DFT DFT calculations H-bonding X-ray structure aminoglutethimide amorphous drug aripiprazole bilastine characterization methods cocrystals controlled release crystal engineering crystal structure crystal structure determination crystallization diclofenac dissolution drug–drug cocrystal ethenzamide eutectic mixture furosemide lidocaine mandelic acid mechanochemical synthesis mechanochemistry melt phase diagram molecular mobility multicomponent crystal multicomponent materials