Reelin and Neuropsychiatric Disorders

Por Ishii, Kazuhiro, Kubo, Ken-ichiro, Nakajima, Kazunori
Publicado no Front Cell Neurosci (2016)

Cellular dynamics of neuronal migration in the hippocampus

Por Hayashi, Kanehiro, Kubo, Ken-ichiro, Kitazawa, Ayako, Nakajima, Kazunori
Publicado no Front Neurosci (2015)

In Utero Bisphenol A Exposure Induces Abnormal Neuronal Migration in the Cerebral Cortex of Mice

Por Ling, Wenting, Endo, Toshihiro, Kubo, Ken-ichiro, Nakajima, Kazunori, Kakeyama, Masaki, Tohyama, Chiharu
Publicado no Front Endocrinol (Lausanne) (2016)

Impaired dendritic growth and positioning of cortical pyramidal neurons by activation of aryl hydrocarbon receptor signaling in the developing mouse

Por Kimura, Eiki, Kubo, Ken-ichiro, Endo, Toshihiro, Ling, Wenting, Nakajima, Kazunori, Kakeyama, Masaki, Tohyama, Chiharu
Publicado no PLoS One (2017)

Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody

Por Utsunomiya-Tate, Naoko, Kubo, Ken-ichiro, Tate, Shin-ichi, Kainosho, Masatsune, Katayama, Eisaku, Nakajima, Kazunori, Mikoshiba, Katsuhiko
Publicado em 2000

Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin α5β1

Por Sekine, Katsutoshi, Kawauchi, Takeshi, Kubo, Ken-ichiro, Honda, Takao, Herz, Joachim, Hattori, Mitsuharu, Kinashi, Tatsuo, Nakajima, Kazunori
Publicado em 2012

Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi

Por Kubo, Ken-ichiro, Tomita, Kenji, Uto, Asuka, Kuroda, Keisuke, Seshadri, Saurav, Cohen, Jared S., Kaibuchi, Kozo, Kamiya, Atsushi, Nakajima, Kazunori
Publicado em 2010

Reelin transiently promotes N-cadherin–dependent neuronal adhesion during mouse cortical development

Por Matsunaga, Yuki, Noda, Mariko, Murakawa, Hideki, Hayashi, Kanehiro, Nagasaka, Arata, Inoue, Seika, Miyata, Takaki, Miura, Takashi, Kubo, Ken-ichiro, Nakajima, Kazunori
Publicado no Proc Natl Acad Sci U S A (2017)

PCM1 is recruited to the centrosome by the cooperative action of DISC1 and BBS4 and is a candidate for psychiatric illness

Por Kamiya, Atsushi, Tan, Perciliz L., Kubo, Ken-ichiro, Engelhard, Caitlin, Ishizuka, Koko, Kubo, Akiharu, Tsukita, Sachiko, Pulver, Ann E., Nakajima, Kazunori, Cascella, Nicola G., Katsanis, Nicholas, Sawa, Akira
Publicado em 2008

DISC1 a key molecular lead in psychiatry and neurodevelopment: No-More Disrupted-in-Schizophrenia

Por Niwa, Minae, Cash-Padgett, Tyler, Kubo, Ken-Ichiro, Saito, Atsushi, Ishii, Kazuhiro, Sumitomo, Akiko, Taniguchi, Yu, Ishizuka, Koko, Jaaro-Peled, Hanna, Tomoda, Toshifumi, Nakajima, Kazunori, Sawa, Akira, Kamiya, Atsushi
Publicado no Mol Psychiatry (2016)

The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain

Por Kanatani, Shigeaki, Honda, Takao, Aramaki, Michihiko, Hayashi, Kanehiro, Kubo, Ken-ichiro, Ishida, Mami, Tanaka, Daisuke H., Kawauchi, Takeshi, Sekine, Katsutoshi, Kusuzawa, Sayaka, Kawasaki, Takahiko, Hirata, Tatsumi, Tabata, Hidenori, Uhlén, Per, Nakajima, Kazunori
Publicado no Proc Natl Acad Sci U S A (2015)

SUMOylation of DISC1: A Potential Role in Neural Progenitor Proliferation in the Developing Cortex

Por Tankou, Stephanie, Ishii, Kazuhiro, Elliott, Christina, Yalla, Krishna C., Day, Jon P., Furukori, Keiko, Kubo, Ken-ichiro, Brandon, Nicholas J., Tang, Qiyi, Hayward, Gary, Nakajima, Kazunori, Houslay, Miles D., Kamiya, Atsushi, Baillie, George S., Ishizuka, Koko, Sawa, Akira
Publicado no Mol Neuropsychiatry (2016)

Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits

Por Niwa, Minae, Kamiya, Atsushi, Murai, Rina, Kubo, Ken-ichiro, Gruber, Aaron J, Tomita, Kenji, Lu, Lingling, Tomisato, Shuta, Jaaro-Peled, Hanna, Seshadri, Saurav, Hiyama, Hideki, Huang, Beverly, Kohda, Kazuhisa, Noda, Yukihiro, O’Donnell, Patricio, Nakajima, Kazunori, Sawa, Akira, Nabeshima, Toshitaka
Publicado em 2010

DISC1-dependent switch from progenitor proliferation to migration in the developing cortex

Por Ishizuka, Koko, Kamiya, Atsushi, Oh, Edwin C., Kanki, Hiroaki, Seshadri, Saurav, Robinson, Jon F., Murdoch, Hannah, Dunlop, Allan J., Kubo, Ken-ichiro, Furukori, Keiko, Huang, Beverly, Zeledon, Mariela, Hayashi-Takagi, Akiko, Okano, Hideyuki, Nakajima, Kazunori, Houslay, Miles D., Katsanis, Nicholas, Sawa, Akira
Publicado em 2011

Association of impaired neuronal migration with cognitive deficits in extremely preterm infants

Por Kubo, Ken-ichiro, Deguchi, Kimiko, Nagai, Taku, Ito, Yukiko, Yoshida, Keitaro, Endo, Toshihiro, Benner, Seico, Shan, Wei, Kitazawa, Ayako, Aramaki, Michihiko, Ishii, Kazuhiro, Shin, Minkyung, Matsunaga, Yuki, Hayashi, Kanehiro, Kakeyama, Masaki, Tohyama, Chiharu, Tanaka, Kenji F., Tanaka, Kohichi, Takashima, Sachio, Nakayama, Masahiro, Itoh, Masayuki, Hirata, Yukio, Antalffy, Barbara, Armstrong, Dawna D., Yamada, Kiyofumi, Inoue, Ken, Nakajima, Kazunori
Publicado no JCI Insight (2017)