Stimulation of mast cells leads to cholesterol accumulation in macrophages in vitro by a mast cell granule-mediated uptake of low density lipoprotein.

Por Kokkonen, J O, Kovanen, P T
Publicado em 1987

Low-density-lipoprotein binding by mast-cell granules. Demonstration of binding of apolipoprotein B to heparin proteoglycan of exocytosed granules.

Por Kokkonen, J O, Kovanen, P T
Publicado em 1987

New approaches to investigating heterogeneity in complex traits

Por Bomprezzi, R, Kovanen, P, Martin, R
Publicado em 2003

MAC technique (morphology antibody chromosomes) in phenotypic identification of proliferating NK and T cells in interleukin-2-stimulated lymphocyte cultures.

Por Kovanen, P E, Timonen, T, Seppälä, I, Knuutila, S
Publicado em 1989

Cellular pathology of homozygous familial hypercholesterolemia.

Por Buja, L. M., Kovanen, P. T., Bilheimer, D. W.
Publicado em 1979

Finnish type of low density lipoprotein receptor gene mutation (FH-Helsinki) deletes exons encoding the carboxy-terminal part of the receptor and creates an internalization-defecti...

Por Aalto-Setälä, K, Helve, E, Kovanen, P T, Kontula, K
Publicado em 1989

Changes in a phospholipid bilayer induced by the hydrolysis of a phospholipase A2 enzyme: a molecular dynamics simulation study.

Por Hyvönen, M T, Oörni, K, Kovanen, P T, Ala-Korpela, M
Publicado em 2001

Intracellular RNA recognition pathway activates strong anti-viral response in human mast cells

Por Lappalainen, J, Rintahaka, J, Kovanen, P T, Matikainen, S, Eklund, K K
Publicado em 2013

Prompt impact of first prospective statin mega-trials on postoperative lipid management of CABG patients: a 20-year follow-up in a single hospital

Por Palomäki, A., Hällberg, V., Ala-Korpela, M., Kovanen, P. T., Malminiemi, K.
Publicado no Lipids Health Dis (2016)

Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits.

Por Kovanen, P T, Brown, M S, Basu, S K, Bilheimer, D W, Goldstein, J L
Publicado em 1981

Chymase in exocytosed rat mast cell granules effectively proteolyzes apolipoprotein AI-containing lipoproteins, so reducing the cholesterol efflux-inducing ability of serum and aor...

Por Lindstedt, L, Lee, M, Castro, G R, Fruchart, J C, Kovanen, P T
Publicado em 1996

Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.

Por Kovanen, P T, Bilheimer, D W, Goldstein, J L, Jaramillo, J J, Brown, M S
Publicado em 1981

Studies on the defect underlying the lysosomal storage of sialic acid in Salla disease. Lysosomal accumulation of sialic acid formed from N-acetyl-mannosamine or derived from low d...

Por Renlund, M, Kovanen, P T, Raivio, K O, Aula, P, Gahmberg, C G, Ehnholm, C
Publicado em 1986

Inhibition of c-kit tyrosine kinase by imatinib mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis

Por Juurikivi, A, Sandler, C, Lindstedt, K, Kovanen, P, Juutilainen, T, Leskinen, M, Maki, T, Eklund, K
Publicado em 2005

The familial hypercholesterolemia (FH)-North Karelia mutation of the low density lipoprotein receptor gene deletes seven nucleotides of exon 6 and is a common cause of FH in Finlan...

Por Koivisto, U M, Turtola, H, Aalto-Setälä, K, Top, B, Frants, R R, Kovanen, P T, Syvänen, A C, Kontula, K
Publicado em 1992

Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models

Por Härmä, V, Knuuttila, M, Virtanen, J, Mirtti, T, Kohonen, P, Kovanen, P, Happonen, A, Kaewphan, S, Ahonen, I, Kallioniemi, O, Grafström, R, Lötjönen, J, Nees, M
Publicado em 2012

Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rab...

Por Schneider, W J, Kovanen, P T, Brown, M S, Goldstein, J L, Utermann, G, Weber, W, Havel, R J, Kotite, L, Kane, J P, Innerarity, T L, Mahley, R W
Publicado em 1981