A pharmacokinetic–pharmacodynamic model predicting tumour growth inhibition after intermittent administration with the mTOR kinase inhibitor AZD8055

le Yates, James W T, Holt, Sarah V, Logie, Armelle, Payne, Kirsty, Woods, Karen, Wilkinson, Robert W, Davies, Barry R, Guichard, Sylvie M
Foilsithe in Br J Pharmacol (2017)

Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation

le Chan, Denice T. Y., Jenkinson, Lesley, Haynes, Stuart W., Austin, Mark, Diamandakis, Agata, Burschowsky, Daniel, Seewooruthun, Chitra, Addyman, Alexandra, Fiedler, Sebastian, Ryman, Stephanie, Whitehouse, Jessica, Slater, Louise H., Gowans, Ellen, Shibata, Yoko, Barnard, Michelle, Wilkinson, Robert W., Vaughan, Tristan J., Holt, Sarah V., Cerundolo, Vincenzo, Carr, Mark D., Groves, Maria A. T.
Foilsithe in Proc Natl Acad Sci U S A (2020)

Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action

le Austin, Mark, Burschowsky, Daniel, Chan, Denice T.Y., Jenkinson, Lesley, Haynes, Stuart, Diamandakis, Agata, Seewooruthun, Chitra, Addyman, Alexandra, Fiedler, Sebastian, Ryman, Stephanie, Whitehouse, Jessica, Slater, Louise H., Hadjinicolaou, Andreas V., Gileadi, Uzi, Gowans, Ellen, Shibata, Yoko, Barnard, Michelle, Kaserer, Teresa, Sharma, Pooja, Luheshi, Nadia M., Wilkinson, Robert W., Vaughan, Tristan J., Holt, Sarah V., Cerundolo, Vincenzo, Carr, Mark D., Groves, Maria A. T.
Foilsithe in MAbs (2020)

The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity

le Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.
Foilsithe in Eur J Med Chem (2016)