The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML

ανά Gerlach, Daniel, Tontsch-Grunt, Ulrike, Baum, Anke, Popow, Johannes, Scharn, Dirk, Hofmann, Marco H., Engelhardt, Harald, Kaya, Onur, Beck, Janina, Schweifer, Norbert, Gerstberger, Thomas, Zuber, Johannes, Savarese, Fabio, Kraut, Norbert
Τόπος έκδοσης Oncogene (2018)

Selective and potent CDK8/19 inhibitors enhance NK cell activity and promote tumor surveillance

ανά Hofmann, Marco H., Mani, Rajeswaran, Engelhardt, Harald, Impagnatiello, Maria A., Carotta, Sebastian, Kerenyi, Marc, Lorenzo-Herrero, Seila, Böttcher, Jark, Scharn, Dirk, Arnhof, Heribert, Zoephel, Andreas, Schnitzer, Renate, Gerstberger, Thomas, Sanderson, Michael P., Rajgolikar, Girish, Goswami, Swagata, Vasu, Sumithira, Ettmayer, Peter, Gonzalez, Segundo, Pearson, Mark, McConnell, Darryl B., Kraut, Norbert, Muthusamy, Natarajan, Moll, Jürgen
Τόπος έκδοσης Mol Cancer Ther (2020)

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

ανά Martin, Laetitia J., Koegl, Manfred, Bader, Gerd, Cockcroft, Xiao-Ling, Fedorov, Oleg, Fiegen, Dennis, Gerstberger, Thomas, Hofmann, Marco H., Hohmann, Anja F., Kessler, Dirk, Knapp, Stefan, Knesl, Petr, Kornigg, Stefan, Müller, Susanne, Nar, Herbert, Rogers, Catherine, Rumpel, Klaus, Schaaf, Otmar, Steurer, Steffen, Tallant, Cynthia, Vakoc, Christopher R., Zeeb, Markus, Zoephel, Andreas, Pearson, Mark, Boehmelt, Guido, McConnell, Darryl
Τόπος έκδοσης J Med Chem (2016)

BI-3406, a potent and selective SOS1::KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition

ανά Hofmann, Marco H., Gmachl, Michael, Ramharter, Juergen, Savarese, Fabio, Gerlach, Daniel, Marszalek, Joseph R., Sanderson, Michael P., Kessler, Dirk, Trapani, Francesca, Arnhof, Heribert, Rumpel, Klaus, Botesteanu, Dana-Adriana, Ettmayer, Peter, Gerstberger, Thomas, Kofink, Christiane, Wunberg, Tobias, Zoephel, Andreas, Fu, Szu-Chin, Teh, Jessica L., Böttcher, Jark, Pototschnig, Nikolai, Schachinger, Franziska, Schipany, Katharina, Lieb, Simone, Vellano, Christopher P., O’Connell, Jonathan C., Mendes, Rachel L., Moll, Jurgen, Petronczki, Mark, Heffernan, Timothy P., Pearson, Mark, McConnell, Darryl B., Kraut, Norbert
Τόπος έκδοσης Cancer Discov (2020)