MACROPHAGE ACTIVATION SYNDROME AND CYTOKINE DIRECTED THERAPIES

por Schulert, Grant S., Grom, Alexei A.
Publicado 2014

Pathogenesis of Macrophage Activation Syndrome and Potential for Cytokine-Directed Therapies

por Schulert, Grant S., Grom, Alexei A.
Publicado en Annu Rev Med (2014)

Update on the pathogenesis and treatment of systemic idiopathic arthritis

por Sikora, Keith A., Grom, Alexei A.
Publicado 2011

Macrophage activation syndrome: advances towards understanding pathogenesis

por Grom, Alexei A., Mellins, Elizabeth D.
Publicado en Curr Opin Rheumatol (2010)

Systemic JIA: New Developments in the Understanding of the Pathophysiology and Therapy

por Vastert, Sebastiaan J., Kuis, Wietse, Grom, Alexei A.
Publicado 2009

Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions

por Mellins, Elizabeth D., Macaubas, Claudia, Grom, Alexei A.
Publicado 2011

Macrophage activation syndrome in the era of biologic therapy

por Grom, Alexei A., Horne, AnnaCarin, De Benedetti, Fabrizio
Publicado en Nat Rev Rheumatol (2016)

The Limited Role of Interferon-γ in Systemic Juvenile Idiopathic Arthritis Cannot Be Explained by Cellular Hyporesponsiveness

por Sikora, Keith A., Fall, Ndate, Thornton, Sherry, Grom, Alexei A.
Publicado 2012

Distinct gene expression signatures characterize strong clinical responders vs non-responders to Canakinumab in children with sJIA

por Verweyen, Emely L, Pickering, Alex, Grom, Alexei A., Schulert, Grant S.
Publicado en Arthritis Rheumatol (2021)

MEVALONATE KINASE DEFICIENCY ASSOCIATED WITH RECURRENT LIVER DYSFUNCTION, MACROPHAGE ACTIVATION SYNDROME AND PERFORIN GENE POLYMORPHISM

por Schulert, Grant S., Bove, Kevin, McMasters, Richard, Campbell, Kathleen, Leslie, Nancy, Grom, Alexei A.
Publicado en Arthritis Care Res (Hoboken) (2015)

Gene Expression Profiles from Peripheral Blood Mononuclear Cells Are Sensitive to Short Processing Delays

por Barnes, Michael G., Grom, Alexei A., Griffin, Thomas A., Colbert, Robert A., Thompson, Susan D.
Publicado 2010

Follistatin-like Protein 1 and the Ferritin/Erythrocyte Sedimentation Rate Ratio Are Potential Biomarkers for Dysregulated Gene Expression and Macrophage Activation Syndrome in Sys...

por Gorelik, Mark, Fall, Ndate, Altaye, Mekibib, Barnes, Michael G., Thompson, Susan D., Grom, Alexei A., Hirsch, Raphael
Publicado 2013

Monocyte microRNA expression in active systemic juvenile idiopathic arthritis implicates miR-125a-5p in polarized monocyte phenotypes

por Schulert, Grant S., Fall, Ndate, Harley, John B., Shen, Nan, Lovell, Daniel J., Thornton, Sherry, Grom, Alexei A.
Publicado en Arthritis Rheumatol (2016)

Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome

por Villanueva, Joyce, Lee, Susan, Giannini, Edward H, Graham, Thomas B, Passo, Murray H, Filipovich, Alexandra, Grom, Alexei A
Publicado 2005

Gene-expression signatures differ between different clinical forms of familial hemophagocytic lymphohistiocytosis

por Sumegi, Janos, Nestheide, Shawnagay V., Barnes, Michael G., Villanueva, Joyce, Zhang, Kejian, Grom, Alexei A., Filipovich, Alexandra H.
Publicado 2013

Novel UNC13D intronic variant disrupting a NFκB enhancer in a patient with recurrent macrophage activation syndrome and systemic juvenile idiopathic arthritis

por Schulert, Grant S., Zhang, Mingce, Husami, Ammar, Fall, Ndate, Brunner, Hermine, Zhang, Kejian, Cron, Randy Q., Grom, Alexei A.
Publicado en Arthritis Rheumatol (2018)

A Multi-parameter Flow Cytometry Analysis Panel to Assess CD163 mRNA and Protein in Monocyte and Macrophage Populations in Hyperinflammatory Diseases

por Thornton, Sherry, Tan, Rachel, Sproles, Alyssa, Do, Thuy, Schick, Jonathan, Grom, Alexei A., DeLay, Monica, Schulert, Grant S.
Publicado en J Immunol (2019)

Neutrophils From Children With Systemic Juvenile Idiopathic Arthritis Exhibit Persistent Proinflammatory Activation Despite Long-Standing Clinically Inactive Disease

por Brown, Rachel A., Henderlight, Maggie, Do, Thuy, Yasin, Shima, Grom, Alexei A., DeLay, Monica, Thornton, Sherry, Schulert, Grant S.
Publicado en Front Immunol (2018)

The use of S100 proteins testing in juvenile idiopathic arthritis and autoinflammatory diseases in a pediatric clinical setting: a retrospective analysis

por Aljaberi, Najla, Tronconi, Elena, Schulert, Grant, Grom, Alexei A., Lovell, Daniel J., Huggins, Jennifer L., Henrickson, Michael, Brunner, Hermine I.
Publicado en Pediatr Rheumatol Online J (2020)

Biologic similarities based on age at onset in oligoarticular and polyarticular subtypes of juvenile idiopathic arthritis

por Barnes, Michael G., Grom, Alexei A., Thompson, Susan D., Griffin, Thomas A., Luyrink, Lorie K., Colbert, Robert A., Glass, David N.
Publicado 2010