Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

by Whitton, Bradleigh, Okamoto, Haruko, Packham, Graham, Crabb, Simon J.
Published in Cancer Med (2018)

V-ATPase inhibition decreases mutant androgen receptor activity in castrate-resistant prostate cancer

by Whitton, Bradleigh, Okamoto, Haruko, Rose-Zerilli, Matthew, Packham, Graham, Crabb, Simon J.
Published in Mol Cancer Ther (2021)

Epigenetic modulators as therapeutic targets in prostate cancer

by Graça, Inês, Pereira-Silva, Eva, Henrique, Rui, Packham, Graham, Crabb, Simon J., Jerónimo, Carmen
Published in Clin Epigenetics (2016)

Can clinically relevant prognostic subsets of breast cancer patients with four or more involved axillary lymph nodes be identified through immunohistochemical biomarkers? A tissue...

by Crabb, Simon J, Bajdik, Chris D, Leung, Samuel, Speers, Caroline H, Kennecke, Hagen, Huntsman, David G, Gelmon, Karen A
Published 2008

Thioflavin S (NSC71948) Interferes with Bcl-2-Associated Athanogene (BAG-1)-Mediated Protein-Protein Interactions

by Sharp, Adam, Crabb, Simon J., Johnson, Peter W. M., Hague, Angela, Cutress, Ramsey, Townsend, Paul A., Ganesan, A., Packham, Graham
Published 2009

ProCAID: a phase I clinical trial to combine the AKT inhibitor AZD5363 with docetaxel and prednisolone chemotherapy for metastatic castration resistant prostate cancer

by Crabb, Simon J., Birtle, Alison J., Martin, Karen, Downs, Nichola, Ratcliffe, Ian, Maishman, Tom, Ellis, Mary, Griffiths, Gareth, Thompson, Stuart, Ksiazek, Lidia, Khoo, Vincent, Jones, Robert J.
Published in Invest New Drugs (2017)

The Prognostic Role of the Change in Neutrophil-to-Lymphocyte Ratio During Neoadjuvant Chemotherapy in Patients with Muscle-Invasive Bladder Cancer: A Retrospective, Multi-Institut...

by Kaiser, Jeenan, Li, Haocheng, North, Scott A., Leibowitz-Amit, Raya, Seah, Jo-An, Morshed, Nisha, Chau, Caroline, Lee-Ying, Richard, Heng, Daniel Y.C., Sridhar, Srikala, Crabb, Simon J., Alimohamed, Nimira S.
Published in Bladder Cancer (2018)

LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models

by Regufe da Mota, Sergio, Bailey, Sarah, Strivens, Rosemary A., Hayden, Annette L., Douglas, Leon R., Duriez, Patrick J., Borrello, M. Teresa, Benelkebir, Hanae, Ganesan, A., Packham, Graham, Crabb, Simon J.
Published in Cancer Cell Int (2018)

Persistent Neutrophil to Lymphocyte Ratio >3 during Treatment with Enzalutamide and Clinical Outcome in Patients with Castration-Resistant Prostate Cancer

by Conteduca, Vincenza, Crabb, Simon J., Jones, Robert J., Caffo, Orazio, Elliott, Tony, Scarpi, Emanuela, Fabbri, Paolo, Derosa, Lisa, Massari, Francesco, Numico, Gianmauro, Zarif, Sunnya, Hanna, Catherine, Maines, Francesca, Joyce, Helen, Lolli, Cristian, De Giorgi, Ugo
Published in PLoS One (2016)

Systemic immune-inflammation index predicts the clinical outcome in patients with metastatic renal cell cancer treated with sunitinib

by Lolli, Cristian, Basso, Umberto, Derosa, Lisa, Scarpi, Emanuela, Sava, Teodoro, Santoni, Matteo, Crabb, Simon J., Massari, Francesco, Aieta, Michele, Conteduca, Vincenza, Maruzzo, Marco, La Russa, Francesca, Wheater, Matthew, Berardi, Rossana, Galli, Luca, De Giorgi, Ugo
Published in Oncotarget (2016)

Phase I trial of DNA methyltransferase inhibitor guadecitabine combined with cisplatin and gemcitabine for solid malignancies including urothelial carcinoma (SPIRE)

by Crabb, Simon J., Danson, Sarah, Catto, James W.F., Hussain, Syed, Chan, Danna, Dunkley, Denise, Downs, Nichola, Marwood, Ellice, Day, Laura, Saunders, Geoff, Light, Michelle, Whitehead, Amy, Ellis, Deborah, Sarwar, Naveed, Enting, Deborah, Birtle, Alison, Johnson, Bernadette, Huddart, Robert, Griffiths, Gareth
Published in Clin Cancer Res (2021)

Body Mass Index in Patients Treated with Cabozantinib for Advanced Renal Cell Carcinoma: A New Prognostic Factor?

by Santoni, Matteo, Massari, Francesco, Bracarda, Sergio, Procopio, Giuseppe, Milella, Michele, De Giorgi, Ugo, Basso, Umberto, Aurilio, Gaetano, Incorvaia, Lorena, Martignetti, Angelo, Rizzo, Mimma, Cartenì, Giacomo, Grande, Enrique, Matrana, Marc R., Crabb, Simon J., Vau, Nuno, Sorgentoni, Giulia, Cimadamore, Alessia, Montironi, Rodolfo, Battelli, Nicola
Published in Diagnostics (Basel) (2021)

Venous Thromboembolism Risk in Patients With Locoregional Urothelial Tract Tumors

by Ramos, Jorge D., Wingate, Jonathan T., Gulati, Roman, Plimack, Elizabeth R., Harshman, Lauren C., Powles, Thomas, Crabb, Simon J., Niegisch, Guenter, Bellmunt, Joaquim, Ladoire, Sylvain, De Giorgi, Ugo, Hussain, Syed, Alva, Ajjai S., Baniel, Jack, Agarwal, Neeraj, Rosenberg, Jonathan E., Vaishampayan, Ulka N., Galsky, Matthew D., Yu, Evan Y.
Published in Clin Genitourin Cancer (2017)

Tumor Downstaging as an Intermediate Endpoint to Assess the Activity of Neoadjuvant Systemic Therapy in Patients With Muscle-Invasive Bladder Cancer

by Martini, Alberto, Jia, Rachel, Ferket, Bart S., Waingankar, Nikhil, Plimack, Elizabeth R., Crabb, Simon J., Harshman, Lauren C., Yu, Evan Y., Powles, Thomas, Rosenberg, Jonathan E., Pal, Sumanta K., Vaishampayan, Ulka N., Necchi, Andrea, Wiklund, N. Peter, Mehrazin, Reza, Mazumdar, Madhu, Sfakianos, John P., Galsky, Matthew D.
Published in Cancer (2019)

Venous thromboembolism in metastatic urothelial carcinoma or variant histologies: incidence, associative factors, and effect on survival

by Ramos, Jorge D., Casey, Martin F., Crabb, Simon J., Bamias, Aristotelis, Harshman, Lauren C., Wong, Yu‐Ning, Bellmunt, Joaquim, De Giorgi, Ugo, Ladoire, Sylvain, Powles, Thomas, Pal, Sumanta K., Niegisch, Guenter, Recine, Federica, Alva, Ajjai, Agarwal, Neeraj, Necchi, Andrea, Vaishampayan, Ulka N., Rosenberg, Jonathan E., Galsky, Matthew D., Yu, Evan Y.
Published in Cancer Med (2016)

COAST (Cisplatin ototoxicity attenuated by aspirin trial): A phase II double-blind, randomised controlled trial to establish if aspirin reduces cisplatin induced hearing-loss

by Crabb, Simon J., Martin, Karen, Abab, Julia, Ratcliffe, Ian, Thornton, Roger, Lineton, Ben, Ellis, Mary, Moody, Ronald, Stanton, Louise, Galanopoulou, Angeliki, Maishman, Tom, Geldart, Thomas, Bayne, Mike, Davies, Joe, Lamb, Carolynn, Popat, Sanjay, Joffe, Johnathan K., Nutting, Chris, Chester, John, Hartley, Andrew, Thomas, Gareth, Ottensmeier, Christian, Huddart, Robert, King, Emma
Published in Eur J Cancer (2017)

Neoadjuvant vs. Adjuvant Chemotherapy in Muscle Invasive Bladder Cancer (MIBC): Analysis From the RISC Database

by Del Bene, Gabriella, Calabrò, Fabio, Giannarelli, Diana, Plimack, Elizabeth R., Harshman, Lauren C., Yu, Evan Y., Crabb, Simon J., Pal, Sumanta Kumar, Alva, Ajjai S., Powles, Thomas, De Giorgi, Ugo, Agarwal, Neeraj, Bamias, Aristotelis, Ladoire, Sylvain, Necchi, Andrea, Vaishampayan, Ulka N., Niegisch, Günter, Bellmunt, Joaquim, Baniel, Jack, Galsky, Matthew D., Sternberg, Cora N.
Published in Front Oncol (2018)

Pan-AKT Inhibitor Capivasertib With Docetaxel and Prednisolone in Metastatic Castration-Resistant Prostate Cancer: A Randomized, Placebo-Controlled Phase II Trial (ProCAID)

by Crabb, Simon J., Griffiths, Gareth, Marwood, Ellice, Dunkley, Denise, Downs, Nichola, Martin, Karen, Light, Michelle, Northey, Josh, Wilding, Sam, Whitehead, Amy, Shaw, Emily, Birtle, Alison J., Bahl, Amit, Elliott, Tony, Westbury, Charlotte, Sundar, Santhanam, Robinson, Angus, Jagdev, Satinder, Kumar, Satish, Rooney, Claire, Salinas-Souza, Carolina, Stephens, Christine, Khoo, Vincent, Jones, Robert J.
Published in J Clin Oncol (2021)

Long non-coding RNAs identify a subset of luminal muscle-invasive bladder cancer patients with favorable prognosis

by de Jong, Joep J., Liu, Yang, Robertson, A. Gordon, Seiler, Roland, Groeneveld, Clarice S., van der Heijden, Michiel S., Wright, Jonathan L., Douglas, James, Dall’Era, Marc, Crabb, Simon J., van Rhijn, Bas W. G., van Kessel, Kim E. M., Davicioni, Elai, Castro, Mauro A. A., Lotan, Yair, Zwarthoff, Ellen C., Black, Peter C., Boormans, Joost L., Gibb, Ewan A.
Published in Genome Med (2019)

Real-World Data on Cabozantinib in Previously Treated Patients with Metastatic Renal Cell Carcinoma: Focus on Sequences and Prognostic Factors

by Santoni, Matteo, Heng, Daniel Y., Bracarda, Sergio, Procopio, Giuseppe, Milella, Michele, Porta, Camillo, Matrana, Marc R., Cartenì, Giacomo, Crabb, Simon J., De Giorgi, Ugo, Basso, Umberto, Masini, Cristina, Calabrò, Fabio, Vitale, Maria Giuseppa, Santini, Daniele, Massari, Francesco, Galli, Luca, Fornarini, Giuseppe, Ricotta, Riccardo, Buti, Sebastiano, Zucali, Paolo, Caffo, Orazio, Morelli, Franco, Carrozza, Francesco, Martignetti, Angelo, Gelibter, Alain, Iacovelli, Roberto, Mosca, Alessandra, Atzori, Francesco, Vau, Nuno, Incorvaia, Lorena, Ortega, Cinzia, Scarpelli, Marina, Lopez-Beltran, Antonio, Cheng, Liang, Paolucci, Vittorio, Graham, Jeffrey, Pierce, Erin, Scagliarini, Sarah, Sepe, Pierangela, Verzoni, Elena, Merler, Sara, Rizzo, Mimma, Sorgentoni, Giulia, Conti, Alessandro, Piva, Francesco, Cimadamore, Alessia, Montironi, Rodolfo, Battelli, Nicola
Published in Cancers (Basel) (2019)