Polyglutamation of methotrexate. Is methotrexate a prodrug?

Por Chabner, B A, Allegra, C J, Curt, G A, Clendeninn, N J, Baram, J, Koizumi, S, Drake, J C, Jolivet, J
Publicado em 1985

Determinants of the sensitivity of human small-cell lung cancer cell lines to methotrexate.

Por Curt, G A, Jolivet, J, Carney, D N, Bailey, B D, Drake, J C, Clendeninn, N J, Chabner, B A
Publicado em 1985

A phase I study of the lipophilic thymidylate synthase inhibitor Thymitaq™ (nolatrexed dihydrochloride) given by 10-day oral administration

Por Jodrell, D I, Bowman, A, Rye, R, Byrne, B, Boddy, A, Rafi, I, Taylor, G A, Johnston, A, Clendeninn, N J
Publicado em 1999