ATPS-55 INFLUENCE OF MAPK AND PI3K PATHWAY MUTATIONS ON RESPONSE TO TARGETED INHIBITORS

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PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition

Bằng McNeill, Robert S., Stroobant, Emily E., Smithberger, Erin, Canoutas, Demitra A., Butler, Madison K., Shelton, Abigail K., Patel, Shrey D., Limas, Juanita C., Skinner, Kasey R., Bash, Ryan E., Schmid, Ralf S., Miller, C. Ryan
Xuất bản năm PLoS One (2018)

Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma

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