A Novel SERCA Inhibitor Demonstrates Synergy with Classic SERCA Inhibitors and Targets Multidrug-Resistant AML

by Bleeker, Nicholas P., Cornea, Razvan L., Thomas, David D., Xing, Chengguo
Published 2013

Structure-Activity Relationship (SAR) Study of Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and the Potential of the Lead agains...

by Aridoss, Gopalakrishnan, Zhou, Bo, Hermanson, David L., Bleeker, Nicholas P., Xing, Chengguo
Published in J Med Chem (2012)

Ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) – a novel scaffold that re-sensitizes multidrug resistant leukemia cells to chemoth...

by Das, Sonia G., Hermanson, David L., Bleeker, Nicholas, Lowman, Xazmin, Li, Yunfang, Kelekar, Ameeta, Xing, Chengguo
Published 2012