Minimizing Drug Exposure in the CNS while Maintaining Good Oral Absorption

per Bagal, Sharan K., Bungay, Peter J.
Publicat 2012

Voltage gated sodium channels as drug discovery targets

per Bagal, Sharan K, Marron, Brian E, Owen, Robert M, Storer, R Ian, Swain, Nigel A
Publicat a Channels (Austin) (2015)

Discovery and Optimization of Selective Na(v)1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

per Bagal, Sharan K., Bungay, Peter J., Denton, Stephen M., Gibson, Karl R., Glossop, Melanie S., Hay, Tanya L., Kemp, Mark I., Lane, Charlotte A. L., Lewis, Mark L., Maw, Graham N., Million, William A., Payne, C. Elizabeth, Poinsard, Cedric, Rawson, David J., Stammen, Blanda L., Stevens, Edward B., Thompson, Lisa R.
Publicat a ACS Med Chem Lett (2015)

A novel selective and orally bioavailable Na(v)1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability

per Payne, Claire Elizabeth, Brown, Adam R, Theile, Jonathon W, Loucif, Alexandre J C, Alexandrou, Aristos J, Fuller, Mathew D, Mahoney, John H, Antonio, Brett M, Gerlach, Aaron C, Printzenhoff, David M, Prime, Rebecca L, Stockbridge, Gillian, Kirkup, Anthony J, Bannon, Anthony W, England, Steve, Chapman, Mark L, Bagal, Sharan, Roeloffs, Rosemarie, Anand, Uma, Anand, Praveen, Bungay, Peter J, Kemp, Mark, Butt, Richard P, Stevens, Edward B
Publicat a Br J Pharmacol (2015)