Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb

Por Wenkui Lan, Joseph J. Valente, Andrew Ilott, Naresh Chennamsetty, Zhihua Liu, Joseph M. Rizzo, Aaron P. Yamniuk, Difei Qiu, Holly M. Shackman, Mark S. Bolgar
Publicado em 2020-01-01