Resultados da pesquisa - safety after failed ((phase 1) OR (phase 2))

Pesquisas alternativas:
phase 1 » phase _ (Expandir a Pesquisa)
phase 2 » phase _ (Expandir a Pesquisa)

1

Phase I/II study of metastatic melanoma patients treated with nivolumab who had progressed after ipilimumab

Phase I/II study of metastatic melanoma patients treated with nivolumab who had progressed after ipilimumab

Por Weber, Jeffrey, Gibney, Geoffrey, Kudchadkar, Ragini, Yu, Bin, Cheng, PingYan, Martinez, Alberto J., Kroeger, Jodie, Richards, Allison, McCormick, Lori, Moberg, Valerie, Cronin, Heather, Zhao, Xiuhua, Schell, Michael, Chen, Yian Ann
Publicado no Cancer Immunol Res (2016)

“... ipilimumab. In this phase I/II study, we assessed nivolumab's safety in 92 ipilimumab refractory patients...”
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2

Phase 1 safety assessment of intrathecal oxytocin

Phase 1 safety assessment of intrathecal oxytocin

Por Eisenach, James C., Tong, Chuanyao, Curry, Regina
Publicado no Anesthesiology (2015)

“... subjective or objective neurologic symptoms. Overall, blood pressure and heart rate increased 1–4 hr after...”
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3

Phase II study of gemcitabine plus S-1 chemotherapy in recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-based chemotherapy

Phase II study of gemcitabine plus S-1 chemotherapy in recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-based chemotherapy

Por PeiJian Peng, XueQing Ou, Hai Liao, YuMeng Liu, SiYang Wang, ZhiBin Cheng, Zhong Lin
Publicado em 2016-05-01

“.... This phase II study was designed to evaluate the efficacy and safety of gemcitabine plus S-1 (GS...”
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4

Phase II study of gemcitabine plus S-1 chemotherapy in recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-based chemotherapy

Phase II study of gemcitabine plus S-1 chemotherapy in recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-based chemotherapy

Por Peng, PeiJian, Ou, XueQing, Liao, Hai, Liu, YuMeng, Wang, SiYang, Cheng, ZhiBin, Lin, Zhong
Publicado no Ther Adv Med Oncol (2016)

“.... This phase II study was designed to evaluate the efficacy and safety of gemcitabine plus S-1 (GS...”
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5

Preoperative chemoradiotherapy using S-1 combined with celecoxib for advanced lower rectal cancer: Phase I/II study

Preoperative chemoradiotherapy using S-1 combined with celecoxib for advanced lower rectal cancer: Phase I/II study

Por Ohira, Gaku, Miyauchi, Hideaki, Hayano, Koichi, Imanishi, Shunsuke, Tochigi, Toru, Maruyama, Tetsuro, Hanaoka, Toshiharu, Okada, Koichiro, Kobayashi, Hiroki, Uno, Takashi, Matsubara, Hisahiro
Publicado no J Anus Rectum Colon (2019)

“... of celecoxib was set at 400 mg/day. In Phase I, the S-1 dose was started at 80 mg/m(2)/day; in Phase II, S-1...”
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6

Preoperative chemoradiotherapy using S-1 combined with celecoxib for advanced lower rectal cancer: Phase I/II study

Preoperative chemoradiotherapy using S-1 combined with celecoxib for advanced lower rectal cancer: Phase I/II study

Por Gaku Ohira, Hideaki Miyauchi, Koichi Hayano, Shunsuke Imanishi, Toru Tochigi, Tetsuro Maruyama, Toshiharu Hanaoka, Koichiro Okada, Hiroki Kobayashi, Takashi Uno, Hisahiro Matsubara
Publicado em 2019-01-01

Assuntos: “...S-1...”
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7

Clinical efficacy and safety of apatinib combined with S-1 in advanced esophageal squamous cell carcinoma

Clinical efficacy and safety of apatinib combined with S-1 in advanced esophageal squamous cell carcinoma

Por Zhao, Jian, Lei, Junmei, Yu, Junyan, Zhang, Chengyan, Song, Xuefeng, Zhang, Ninggang, Wang, Yusheng, Zhang, Suxiang
Publicado no Invest New Drugs (2019)

Assuntos: “...Phase II Studies...”
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8

Anti PD-L1 DUrvalumab combined with Cetuximab and RadiOtherapy in locally advanced squamous cell carcinoma of the head and neck: A phase I/II study (DUCRO)

Anti PD-L1 DUrvalumab combined with Cetuximab and RadiOtherapy in locally advanced squamous cell carcinoma of the head and neck: A phase I/II study (DUCRO)

Por Bonomo, Pierluigi, Desideri, Isacco, Loi, Mauro, Mangoni, Monica, Sottili, Mariangela, Marrazzo, Livia, Talamonti, Cinzia, Greto, Daniela, Pallotta, Stefania, Livi, Lorenzo
Publicado no Clin Transl Radiat Oncol (2018)

“..., multi-center, single-arm, phase I/II study, enrolled patients will receive Radiotherapy (RT) (69.9 Gy...”
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9

A single-arm phase II trial of combined chemotherapy with S-1, oral leucovorin, and bevacizumab in heavily pre-treated patients with metastatic colorectal cancer

A single-arm phase II trial of combined chemotherapy with S-1, oral leucovorin, and bevacizumab...

Por Yamaguchi, Kazuhisa, Taniguchi, Hiroya, Komori, Azusa, Narita, Yukiya, Nitta, Sohei, Nomura, Motoo, Kadowaki, Shigenori, Takahari, Daisuke, Ura, Takashi, Andoh, Masashi, Muro, Kei, Mori, Keita, Igarashi, Yoshinori
Publicado no BMC Cancer (2015)

“...-centre phase-II trial to evaluate the safety and efficacy of SL/Bev combination chemotherapy as mCRC...”
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10

Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab

Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab

Por Bégin, Philippe, Dominguez, Tina, Wilson, Shruti P, Bacal, Liane, Mehrotra, Anjuli, Kausch, Bethany, Trela, Anthony, Tavassoli, Morvarid, Hoyte, Elisabeth, O’Riordan, Gerri, Blakemore, Alanna, Seki, Scott, Hamilton, Robert G, Nadeau, Kari C
Publicado em 2014

“... protein. OBJECTIVE: To evaluate the safety and dose tolerability of a Phase 1 Single Site OIT protocol...”
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11

Modified FOLFIRINOX as a Second-Line Treatment for Patients with Gemcitabine-Failed Advanced Biliary Tract Cancer: A Prospective Multicenter Phase II Study

Modified FOLFIRINOX as a Second-Line Treatment for Patients with Gemcitabine-Failed Advanced Biliary Tract Cancer: A Prospective Multicenter Phase II Study

Por Yong-Pyo Lee, Sung Yong Oh, Kwang Min Kim, Se-Il Go, Jung Hoon Kim, Seok Jae Huh, Jung Hun Kang, Jun Ho Ji
Publicado em 2022-04-01

“...-line treatment, but its efficacy was modest. In this phase II study, we looked at the efficacy...”
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12

Phase I/II clinical trial using HLA-A24-restricted peptide vaccine derived from KIF20A for patients with advanced pancreatic cancer

Phase I/II clinical trial using HLA-A24-restricted peptide vaccine derived from KIF20A for patients with advanced pancreatic cancer

Por Asahara, Shingo, Takeda, Kazuyoshi, Yamao, Kenji, Maguchi, Hiroyuki, Yamaue, Hiroki
Publicado no J Transl Med (2013)

“..., in whom gemcitabine-based therapy had failed. In phase I study, KIF20A-66 peptide was subcutaneously...”
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13

$Vascular effects, efficacy and safety of nintedanib in patients with advanced, refractory colorectal cancer: a prospective phase I subanalysis$

Vascular effects, efficacy and safety of nintedanib in patients with advanced, refractory colorectal cancer: a prospective phase I subanalysis

Por Mross, Klaus, Büchert, Martin, Frost, Annette, Medinger, Michael, Stopfer, Peter, Studeny, Matus, Kaiser, Rolf
Publicado em 2014

“... signalling, as well as RET and Flt3. The maximum tolerated dose of nintedanib was evaluated in a phase I...”
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14

Results of a Phase II Study to Evaluate the Efficacy of Docetaxel and Carboplatin in Metastatic Malignant Melanoma Patients Who Failed First-Line Therapy Containing Dacarbazine

Results of a Phase II Study to Evaluate the Efficacy of Docetaxel and Carboplatin in Metastatic...

Por Lee, Choong-kun, Jung, Minkyu, Choi, Hye Jin, Kim, Hye Ryun, Kim, Hyo Song, Roh, Mi Ryung, Ahn, Joong Bae, Chung, Hyun Cheol, Heo, Su Jin, Rha, Sun Young, Shin, Sang Joon
Publicado no Cancer Res Treat (2015)

“... modest efficacy. MATERIALS AND METHODS: We conducted a phase II, open-label, single-arm study to test...”
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15

Results of a phase-I/II randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis

Results of a phase-I/II randomized, masked, placebo-controlled trial of recombinant human...

Por Moreland, Larry, Gugliotti, Ron, King, Kevin, Chase, Walter, Weisman, Michael, Greco, Thomas, Fife, Rose, Korn, Joseph, Simms, Robert, Tesser, John, Hillson, Jan, Caldwell, Jacques, Schnitzer, Thomas, Lyons, David, Schwertschlag, Ullrich
Publicado em 2001

“... of synovitis and the histologic lesion scores in the joints. The goal of this phase-I/II study in adults...”
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16

A 12 Week, Open Label, Phase I/IIa Study Using Apatone(®) for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy

A 12 Week, Open Label, Phase I/IIa Study Using Apatone(®) for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy

Por Tareen, Basir, Summers, Jack L., Jamison, James M., Neal, Deborah R., McGuire, Karen, Gerson, Lowell, Diokno, Ananias
Publicado em 2008

“...: Seventeen patients with 2 successive rises in PSA after failure of standard local therapy were treated...”
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17

Phase II Study of Olaparib (AZD-2281) After Standard Systemic Therapies for Disseminated Colorectal Cancer

Phase II Study of Olaparib (AZD-2281) After Standard Systemic Therapies for Disseminated Colorectal Cancer

Por Leichman, Lawrence, Groshen, Susan, O’Neil, Bert H., Messersmith, Wells, Berlin, Jordan, Chan, Emily, Leichman, Cynthia G., Cohen, Steven J., Cohen, Deirdre, Lenz, Heinz-Josef, Gold, Philip, Boman, Bruce, Fielding, Anitra, Locker, Gershon, Cason, Ronald C., Hamilton, Stan R., Hochster, Howard S.
Publicado no Oncologist (2016)

“...-label phase II trial testing olaparib 400 mg p.o. b.i.d. for patients with disseminated, measurable CRC...”
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18

$Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer$

Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets...

Por Trarbach, T, Moehler, M, Heinemann, V, Köhne, C-H, Przyborek, M, Schulz, C, Sneller, V, Gallant, G, Kanzler, S
Publicado em 2010

“... (TRAIL-R1). METHODS: This phase II multicentre study was designed to evaluate the efficacy and safety...”
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19

Phase 2 ventricular arrhythmias in acute myocardial infarction: a neglected target for therapeutic antiarrhythmic drug development and for safety pharmacology evaluation

Phase 2 ventricular arrhythmias in acute myocardial infarction: a neglected target for therapeutic...

Por Clements-Jewery, Hugh, Hearse, David J, Curtis, Michael J
Publicado em 2005

“... to the emerging field of safety pharmacology. It is concluded that suppression of phase 2 as well as phase 1 VF...”
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20

Phase II Trial of Continuous Regorafenib Dosing in Patients with Gastrointestinal Stromal Tumors After Failure of Imatinib and Sunitinib

Phase II Trial of Continuous Regorafenib Dosing in Patients with Gastrointestinal Stromal Tumors After Failure of Imatinib and Sunitinib

Por Kim, Jae‐Joon, Ryu, Min‐Hee, Yoo, Changhoon, Beck, Mo Youl, Ma, Jung Eun, Kang, Yoon‐Koo
Publicado no Oncologist (2019)

“... period has also been noted in some patients. Therefore, we conducted this phase II trial to evaluate...”
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