Resultados da pesquisa - ((drug dnaer) OR (drug dna)) ((devel ther) OR (novel ther))

101

In vivo study of doxorubicin-loaded cell-penetrating peptide-modified pH-sensitive liposomes: biocompatibility, bio-distribution, and pharmacodynamics in BALB/c nude mice bearing h...

Por Ding, Yuan, Cui, Wei, Sun, Dan, Wang, Gui-Ling, Hei, Yu, Meng, Shuai, Chen, Jian-Hua, Xie, Ying, Wang, Zhi-Qiang
Publicado no Drug Des Devel Ther (2017)

“...In vivo evaluation of drug delivery vectors is essential for clinical translation. In BALB/c nude...”
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102

A carregar...

Safety and efficacy of azacitidine in myelodysplastic syndromes

Por Vigil, Carlos E, Martin-Santos, Taida, Garcia-Manero, Guillermo
Publicado em 2010

“... are reviewed. SUMMARY: Azacitidine is the first drug FDA-approved for the treatment of myelodysplastic...”
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103

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Pancreatic cancer: optimizing treatment options, new, and emerging targeted therapies

Por Chiorean, Elena Gabriela, Coveler, Andrew L
Publicado no Drug Des Devel Ther (2015)

“... the core pathways reproducibly shown to lead the development and progression of this disease, DNA repair...”
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104

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Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells

Por Brard, Laurent, Singh, Rakesh K, Kim, Kyu Kwang, Lange, Thilo S, Sholler, Giselle L Saulier
Publicado em 2009

“...), a novel indole ethyl isothiocyanate analog. We now describe its selective cytotoxicity in both...”
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105

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Lost expression of ADAMTS5 protein associates with progression and poor prognosis of hepatocellular carcinoma

Por Li, Chongyi, Xiong, Yanli, Yang, Xueqin, Wang, Lin’ang, Zhang, Shiheng, Dai, Nan, Li, Mengxia, Ren, Tao, Yang, Yuxin, Zhou, Shu-Feng, Gan, Lixia, Wang, Dong
Publicado no Drug Des Devel Ther (2015)

“... and for ADAMTS5 manipulation. ADAMTS5 cDNA was stably transfected into HCC cells and ADAMTS5 expression assessed...”
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106

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Tenofovir alafenamide in the treatment of chronic hepatitis B: design, development, and place in therapy

Por Ogawa, Eiichi, Furusyo, Norihiro, Nguyen, Mindie H
Publicado no Drug Des Devel Ther (2017)

“...Tenofovir alafenamide (TAF), a novel prodrug of tenofovir (TFV), has been approved...”
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107

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Current and developing therapeutic agents in the treatment of Chagas disease

Por Apt, Werner
Publicado em 2010

“... and middle determinant chronic, due to the fact that DNA of the parasite can be demonstrated by PCR...”
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108

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Gene medicine for cancer treatment: Commercially available medicine and accumulated clinical data in China

Por Ma, Guangyu, Shimada, Hideaki, Hiroshima, Kenzo, Tada, Yuji, Suzuki, Nobuo, Tagawa, Masatoshi
Publicado em 2009

“...Loss of p53 function compromises genetic homeostasis, which induces deregulated DNA replication...”
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109

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Mesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts

Por Zhu, Yin, Cheng, Ming, Yang, Zhen, Zeng, Chun-Yan, Chen, Jiang, Xie, Yong, Luo, Shi-Wen, Zhang, Kun-He, Zhou, Shu-Feng, Lu, Nong-Hua
Publicado no Drug Des Devel Ther (2014)

“... of tumors. Gastric cancer is the third leading cause of worldwide cancer mortality, and novel treatment...”
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110

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N(α)-1, 3-Benzenedicarbonyl-Bis-(Amino Acid) and Dipeptide Candidates: Synthesis, Cytotoxic, Antimicrobial and Molecular Docking Investigation

Por Naglah, Ahmed M, Moustafa, Gaber O, Elhenawy, Ahmed A, Mounier, Marwa M, El-Sayed, Heba, Al-Omar, Mohamed A, Almehizia, Abdulrahman A, Bhat, Mashooq A
Publicado no Drug Des Devel Ther (2021)

“... for the novel synthesized linear peptide is Nα-1, 3-benzenedicarbonyl-bis-(Amino acids)-X, (3–11). A...”
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111

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Stoichiometrically Governed Curcumin Solid Dispersion and Its Cytotoxic Evaluation on Colorectal Adenocarcinoma Cells

Por Mohamed, Jamal Moideen Muthu, Alqahtani, Ali, Ahmad, Fazil, Krishnaraju, V, Kalpana, K
Publicado no Drug Des Devel Ther (2020)

“..., scanning electron microscopy, dynamic light scattering study, and the novel dyeing test. In vitro drug...”
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112

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Radium 223 dichloride for prostate cancer treatment

Por Deshayes, Emmanuel, Roumiguie, Mathieu, Thibault, Constance, Beuzeboc, Philippe, Cachin, Florent, Hennequin, Christophe, Huglo, Damien, Rozet, François, Kassab-Chahmi, Diana, Rebillard, Xavier, Houédé, Nadine
Publicado no Drug Des Devel Ther (2017)

“... that induces irreversible DNA double-strand breaks and consequently tumor cell death. Radium-223 dichloride...”
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113

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Current progress in the development of a prophylactic vaccine for HIV-1

Por Gamble, Lena J, Matthews, Qiana L
Publicado em 2010

“... traditional vaccination attempts, induction of broadly neutralizing antibody production, DNA vaccines, and use...”
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114

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Polyethylenimine-mediated gene delivery to the lung and therapeutic applications

Por Di Gioia, Sante, Conese, Massimo
Publicado em 2009

“... to the lung. PEI has some advantages over other polycations in that it combines strong DNA compaction capacity...”
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115

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Plasmid pORF-hTRAIL targeting to glioma using transferrin-modified polyamidoamine dendrimer

Por Gao, Song, Li, Jianfeng, Jiang, Chen, Hong, Bo, Hao, Bing
Publicado no Drug Des Devel Ther (2015)

“...A gene drug delivery system for glioma therapy based on transferrin (Tf)-modified polyamidoamine...”
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116

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Emerging options in growth hormone therapy: an update

Por Kemp, Stephen F, Frindik, J Paul
Publicado em 2011

“.... In 1985, GH produced by recombinant DNA techniques became available, expanding its possible uses. Since...”
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117

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Role of janus kinase inhibitors in the treatment of alopecia areata

Por Triyangkulsri, Korn, Suchonwanit, Poonkiat
Publicado no Drug Des Devel Ther (2018)

“.... Currently, there is no US Food and Drug Administration-approved treatment for AA. Many off-label treatments...”
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118

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Is increasing the dose of Entecavir effective in partial virological responders?

Por Erturk, Ayse, Adnan Akdogan, Remzi, Parlak, Emine, Cure, Erkan, Cumhur Cure, Medine, Ozturk, Cinar
Publicado em 2014

“... of the treatment, those with detectable hepatitis B virus (HBV-DNA) were randomized to either ETV 0.5 mg or 1 mg...”
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119

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In silico and in vivo characterization of cabralealactone, solasodin and salvadorin in a rat model: potential anti-inflammatory agents

Por Malik, Arif, Arooj, Mahwish, Butt, Tariq Tahir, Zahid, Sara, Zahid, Fatima, Jafar, Tassadaq Hussain, Waquar, Sulayman, Gan, Siew Hua, Ahmad, Sarfraz, Mirza, Muhammad Usman
Publicado no Drug Des Devel Ther (2018)

“...BACKGROUND: The present study investigates the hepato- and DNA-protective effects of standardized...”
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120

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Targeted inhibition of mammalian target of rapamycin (mTOR) enhances radiosensitivity in pancreatic carcinoma cells

Por Dai, Zhi-Jun, Gao, Jie, Kang, Hua-Feng, Ma, Yu-Guang, Ma, Xiao-Bin, Lu, Wang-Feng, Lin, Shuai, Ma, Hong-Bing, Wang, Xi-Jing, Wu, Wen-Ying
Publicado em 2013

“... of the cell cycle. Complementary DNA (cDNA) microarray and reverse transcription polymerase chain reaction (RT...”
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