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1

New Mandelalides Expand a Macrolide Series of Mitochondrial Inhibitors

New Mandelalides Expand a Macrolide Series of Mitochondrial Inhibitors

Por Nazari, Mohamad, Serrill, Jeffrey D., Wan, Xuemei, Nguyen, Minh H., Anklin, Clemens, Gallegos, David A., Smith, Amos B., Ishmael, Jane E., McPhail, Kerry L.
Publicado no J Med Chem (2017)

“... of additional natural congeners, mandelalides E–L (5–12), and the supply of synthetic compounds 1 and 12...”
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2

Inositol hexakisphosphate stimulates non-Ca(2+)-mediated and primes Ca(2+)-mediated exocytosis of insulin by activation of protein kinase C

Inositol hexakisphosphate stimulates non-Ca(2+)-mediated and primes Ca(2+)-mediated exocytosis of insulin by activation of protein kinase C

Por Efanov, Alexandre M., Zaitsev, Sergei V., Berggren, Per-Olof
Publicado em 1997

“...d-myo-inositol 1,2,3,4,5,6-hexakisphosphate (InsP(6)), formed via complex pathways of inositol...”
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3

NSC 622124 Inhibits Human Eg5 and Other Kinesins Via Interaction with the Conserved Microtubule-Binding Site

NSC 622124 Inhibits Human Eg5 and Other Kinesins Via Interaction with the Conserved Microtubule-Binding Site

Por Learman, Sarah S., Kim, Catherine D., Stevens, Nathaniel S., Kim, Sunyoung, Wojcik, Edward J., Walker, Richard A.
Publicado em 2009

“... of an HsEg5•NSC622124 complex revealed that segments of the α3 and α5 helices map to the inhibitor-binding...”
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4

Cost Burden of Post Stroke Condition in Nigeria: A Pilot Study

Cost Burden of Post Stroke Condition in Nigeria: A Pilot Study

Por Birabi, Bridget N, Oke, Kayode Israel, Dienye, Paul O., Okafor, Udoka Chris
Publicado no Glob J Health Sci (2012)

“...AIM: Estimation of cost burden of a disease condition is a very important part of health care...”
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5

Identification of a membrane-cytoskeletal complex containing the cell adhesion molecule uvomorulin (E-cadherin), ankyrin, and fodrin in Madin- Darby canine kidney epithelial cells

Identification of a membrane-cytoskeletal complex containing the cell adhesion molecule uvomorulin...

Publicado em 1990

“... now examined cell extracts for protein complexes containing the cell adhesion molecule uvomorulin...”
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6

Pulsatility and high shear stress deteriorate barrier phenotype in brain microvascular endothelium

Pulsatility and high shear stress deteriorate barrier phenotype in brain microvascular endothelium

Por Garcia-Polite, Fernando, Martorell, Jordi, Del Rey-Puech, Paula, Melgar-Lesmes, Pedro, O’Brien, Caroline C, Roquer, Jaume, Ois, Angel, Principe, Alessandro, Edelman, Elazer R, Balcells, Mercedes
Publicado no J Cereb Blood Flow Metab (2016)

“... cells. We suggest in this paper a complex response of endothelial cells to aberrant forces under...”
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7

Rab5 Enhances Classical Swine Fever Virus Proliferation and Interacts with Viral NS4B Protein to Facilitate Formation of NS4B Related Complex

Rab5 Enhances Classical Swine Fever Virus Proliferation and Interacts with Viral NS4B Protein to Facilitate Formation of NS4B Related Complex

Por Lin, Jihui, Wang, Chengbao, Zhang, Longxiang, Wang, Tao, Zhang, Jing, Liang, Wulong, Li, Cheng, Qian, Gui, Ouyang, Yueling, Guo, Kangkang, Zhang, Yanming
Publicado no Front Microbiol (2017)

“... related complexes. Furthermore, it was observed that NS4B co-localized with viral NS3 and NS5A proteins...”
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8

The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling

The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling

Por Goetz, Sarah C., Bangs, Fiona, Barrington, Chloe L., Katsanis, Nicholas, Anderson, Kathryn V.
Publicado no PLoS One (2017)

“...-protein complexes important for the transport of cargo to the basal body and/or into the cilium. A key...”
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9

Upstream stimulatory factor activates the vasopressin promoter via multiple motifs, including a non-canonical E-box.

Upstream stimulatory factor activates the vasopressin promoter via multiple motifs, including a non-canonical E-box.

Por Coulson, Judy M, Edgson, Jodie L, Marshall-Jones, Zoe V, Mulgrew, Robert, Quinn, John P, Woll, Penella J
Publicado em 2003

“... in vitro. We now report that USF overexpression in non-SCLC (NSCLC) cells can functionally activate...”
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10

Ets1 and Elk1 transcription factors regulate cancerous inhibitor of protein phosphatase 2A expression in cervical and endometrial carcinoma cells

Ets1 and Elk1 transcription factors regulate cancerous inhibitor of protein phosphatase 2A expression in cervical and endometrial carcinoma cells

Por Pallai, Rajash, Bhaskar, Aishwarya, Sodi, Valerie, Rice, Lyndi M.
Publicado em 2012

“... promoter region of the human CIP2A gene in cervical, endometrial and liver carcinoma cells. The 5′ flanking...”
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11

Analysis of 7,8-Dihydro-8-oxo-2′-deoxyguanosine in Cellular DNA during Oxidative Stress

Analysis of 7,8-Dihydro-8-oxo-2′-deoxyguanosine in Cellular DNA during Oxidative Stress

Por Mangal, Dipti, Vudathala, Daljit, Park, Jong-Heum, Lee, Seon Hwa, Penning, Trevor M., Blair, Ian A.
Publicado em 2009

“... that the basal 8-oxo-dGuo level in DNA from human bronchoalveolar H358 cells was 2.2 ± 0.4 8-oxo-dGuo/10(7) dGuo...”
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12

The ly-6 protein, lynx1, is an endogenous inhibitor of nicotinic signaling in airway epithelium

The ly-6 protein, lynx1, is an endogenous inhibitor of nicotinic signaling in airway epithelium

Por Fu, Xiao Wen, Rekow, Stephen S., Spindel, Eliot R.
Publicado em 2012

“... in neurons by altering receptor sensitivity and desensitization. We now report that lynx1 forms a complex...”
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13

Pulmonary diesel particulate increases susceptibility to myocardial ischemia/reperfusion injury via activation of sensory TRPV1 and β1 adrenoreceptors

Pulmonary diesel particulate increases susceptibility to myocardial ischemia/reperfusion injury via activation of sensory TRPV1 and β1 adrenoreceptors

Por Robertson, Sarah, Thomson, Ashleigh L, Carter, Rod, Stott, Holly R, Shaw, Catherine A, Hadoke, Patrick W F, Newby, David E, Miller, Mark R, Gray, Gillian A
Publicado em 2014

“...BACKGROUND: Clinical studies have now confirmed the link between short-term exposure to elevated...”
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14

Altered Tregs Differentiation and Impaired Autophagy Correlate to Atherosclerotic Disease

Altered Tregs Differentiation and Impaired Autophagy Correlate to Atherosclerotic Disease

Por Sara Mandatori, Ilenia Pacella, Ilenia Pacella, Vincenzo Marzolla, Caterina Mammi, Donatella Starace, Fabrizio Padula, Laura Vitiello, Andrea Armani, Carmine Savoia, Maurizio Taurino, Daniela De Zio, Claudia Giampietri, Silvia Piconese, Silvia Piconese, Francesco Cecconi, Francesco Cecconi, Francesco Cecconi, Massimiliano Caprio, Massimiliano Caprio, Antonio Filippini
Publicado em 2020-03-01

Assuntos: “...regulatory T cells...”
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15

The Psychos Are Coming, the Psychos Are Coming … They’re Already Here

The Psychos Are Coming, the Psychos Are Coming … They’re Already Here

Por Edmund Weisberg
Publicado em 2016-06-01

“... of companies, can cause widespread human suffering. Contagion turns the concept of scapegoating on its head...”
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16

Poster Session B

Poster Session B

Publicado no Mol Cell Proteomics (2017)

“... S. Wunschel(2), Karen L. Wahl(2), Natalie Heller(3), Kristin H. Jarman(3) (1)Pacific Northwest National...”
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17

ATAC-king the complexity of SAGA during evolution

ATAC-king the complexity of SAGA during evolution

Por Spedale, Gianpiero, Timmers, H.Th. Marc, Pijnappel, W.W.M. Pim
Publicado em 2012

“...The yeast SAGA (Spt–Ada–Gcn5–acetyltransferase) coactivator complex exerts functions in gene...”
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18

Tumor Dormancy Induced by Downregulation of Urokinase Receptor in Human Carcinoma Involves Integrin and MAPK Signaling

Tumor Dormancy Induced by Downregulation of Urokinase Receptor in Human Carcinoma Involves Integrin and MAPK Signaling

Por Ghiso, Julio A. Aguirre, Kovalski, Katherine, Ossowski, Liliana
Publicado em 1999

“...%) reduction in the urokinase plasminogen activator receptor (uPAR) level in human carcinoma HEp3 cells, while...”
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19

E-box motifs within the human vasopressin gene promoter contribute to a major enhancer in small-cell lung cancer.

E-box motifs within the human vasopressin gene promoter contribute to a major enhancer in small-cell lung cancer.

Por Coulson, J M, Fiskerstrand, C E, Woll, P J, Quinn, J P
Publicado em 1999

“... but pathologically expressed by small-cell lung cancer (SCLC). A minimal 65 bp AVP promoter can restrict basal...”
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20

A novel, transformation-relevant activation domain in Fos proteins.

A novel, transformation-relevant activation domain in Fos proteins.

Por Funk, M, Poensgen, B, Graulich, W, Jerome, V, Müller, R
Publicado em 1997

“... complex, and that the C-TM plays a crucial role in this cooperation. These observations can...”
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