Resultados da pesquisa - (( j a camp can now ) OR ((( j nayl clamp j now ) OR ( j led con ((canada ne) OR (canada nee)) ))))

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Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction.

Por Zhao, L J, Giam, C Z
Publicado em 1992

“... in the viral enhancer. The HTLV-I 21-bp repeat contains a TGACGT motif that is homologous to the cAMP...”
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International Union of Basic and Clinical Pharmacology. XCIII. The Parathyroid Hormone Receptors—Family B G Protein–Coupled Receptors

Por Gardella, Thomas J., Vilardaga, Jean-Pierre
Publicado no Pharmacol Rev (2015)

“... and biochemical approaches, and the data obtained support a basic “two-site” mode of ligand binding now thought...”
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Protein kinase A activation inhibits DUX4 gene expression in myotubes from patients with facioscapulohumeral muscular dystrophy

Por Cruz, Joseph M., Hupper, Nicole, Wilson, Liz S., Concannon, John B., Wang, Yuan, Oberhauser, Berndt, Patora-Komisarska, Krystyna, Zhang, Yunyu, Glass, David J., Trendelenburg, Anne-Ulrike, Clarke, Brian A.
Publicado no J Biol Chem (2018)

“... individuals with FSHD. Of note, we found that cAMP production reduces DUX4 expression through a protein kinase...”
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Mutations in the protein kinase A R1α regulatory subunit cause familial cardiac myxomas and Carney complex

Por Casey, Mairead, Vaughan, Carl J., He, Jie, Hatcher, Cathy J., Winter, Jordan M., Weremowicz, Stanislawa, Montgomery, Kate, Kucherlapati, Raju, Morton, Cynthia C., Basson, Craig T.
Publicado em 2000

“.... We now demonstrate that the PRKAR1α gene encoding the R1α regulatory subunit of cAMP-dependent...”
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Insights into GPCR pharmacology from the measurement of changes in intracellular cyclic AMP; advantages and pitfalls of differing methodologies

Por Hill, Stephen J, Williams, Christine, May, Lauren T
Publicado em 2010

“...It is clear that the G protein-coupled receptor family play a key role in the pharmaceutical...”
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Shiga toxin (Stx)1B and Stx2B induce von Willebrand factor secretion from human umbilical vein endothelial cells through different signaling pathways

Por Liu, Fang, Huang, Jing, Sadler, J. Evan
Publicado em 2011

“... endothelial cells (HUVECs), and Stx2B can cause thrombotic microangiopathy in Adamts13(−/−) mice. We have now...”
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Congenital hyperthyroidism caused by a solitary toxic adenoma harboring a novel somatic mutation...

Por Kopp, P, Muirhead, S, Jourdain, N, Gu, W X, Jameson, J L, Rodd, C
Publicado em 1997

“...Activating somatic mutations in the thyrotropin (TSH) receptor have been identified as a cause...”
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The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery

Por Nikulina, Elena, Tidwell, J. Lille, Dai, Hai Ning, Bregman, Barbara S., Filbin, Marie T.
Publicado em 2004

“.... Prophylactic injection of cAMP, however, is useless as therapy for spinal injuries. We now show...”
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Phosphorylation switches specific for the cardiac isoform of myosin binding protein-C: a modulator of cardiac contraction?

Por Gautel, M, Zuffardi, O, Freiburg, A, Labeit, S
Publicado em 1995

“...Cardiac myosin binding protein-C (cardiac MyBP-C, cardiac C protein) belongs to a family...”
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Rapid Actions of Xenoestrogens Disrupt Normal Estrogenic Signaling

Por Watson, Cheryl S., Hu, Guangzhen, Paulucci-Holthauzen, Adriana A.
Publicado em 2013

“... a range of rapid signals/protein activations by XEs including: calcium channels, cAMP/PKA, MAPKs, G...”
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ΔRaf-1:ER* Bypasses the Cyclic AMP Block of Extracellular Signal-Regulated Kinase 1 and 2 Activation but Not CDK2 Activation or Cell Cycle Reentry

Por Balmanno, Kathryn, Millar, Tracy, McMahon, Martin, Cook, Simon J.
Publicado em 2003

“...Elevation of cellular cyclic AMP (cAMP) levels inhibits cell cycle reentry in a variety of cell...”
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In vitro desensitization of isolated nephron segments to vasopressin.

Por Dublineau, I, Pradelles, P, de Rouffignac, C, Elalouf, J M
Publicado em 1990

“... response to vasopressin in vivo and by a reduced cAMP accumulation in the cortical thick ascending limb...”
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Activation of muscarinic acetylcholine receptors via their allosteric binding sites.

Por Jakubík, J, Bacáková, L, Lisá, V, el-Fakahany, E E, Tucek, S
Publicado em 1996

“... also affects the interaction between the receptors and the G proteins. We have now found...”
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Direct Biochemical Measurements of Signal Relay during Dictyostelium Development

Por Das, Satarupa, Rericha, Erin C., Bagorda, Anna, Parent, Carole A.
Publicado em 2011

“... directionally and form characteristic chains of cells called streams. We now report that cAMP relay can...”
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cAMP-independent olfactory transduction of amino acids in Xenopus laevis tadpoles

Por Manzini, Ivan, Schild, Detlev
Publicado em 2003

“... conclusions using the calcium imaging technique in the mucosa slice. The above question can now unambiguously...”
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Cell-free transcription directed by the 422 adipose P2 gene promoter: activation by the CCAAT/enhancer binding protein.

Por Cheneval, D, Christy, R J, Geiman, D, Cornelius, P, Lane, M D
Publicado em 1991

“...Previous investigations have shown that CCAAT/enhancer binding protein (C/EBP) can function as a...”
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Molecular Epidemiology of Aspergillus fumigatus Isolates Harboring the TR(34)/L98H Azole Resistance Mechanism

Por Camps, Simone M. T., Rijs, Antonius J. M. M., Klaassen, Corné H. W., Meis, Jacques F., O'Gorman, Céline M., Dyer, Paul S., Melchers, Willem J. G., Verweij, Paul E.
Publicado em 2012

“... and involves the TR(34)/L98H mutations in cyp51A. This resistance mechanism is now also increasingly being...”
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Phase-Variable Expression of lptA Modulates the Resistance of Neisseria gonorrhoeae to Cationic Antimicrobial Peptides

Por Kandler, Justin L., Joseph, Sandeep J., Balthazar, Jacqueline T., Dhulipala, Vijaya, Read, Timothy D., Jerse, Ann E., Shafer, William M.
Publicado em 2014

“... experimental infection. We now report that the lptA gene, which encodes the PEA transferase responsible...”
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Multiple Serotonergic Mechanisms Contributing to Sensitization in Aplysia: Evidence of Diverse Serotonin Receptor Subtypes

Por Barbas, Demian, DesGroseillers, Luc, Castellucci, Vincent F., Carew, Thomas J., Marinesco, Stéphane
Publicado em 2003

“... recruited into action during learning in Aplysia can now be addressed from a molecular point of view....”
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Regulator of Calcineurin 1 Modulates Expression of Innate Anxiety and Anxiogenic Responses to Selective Serotonin Reuptake Inhibitor Treatment

Por Hoeffer, Charles A., Wong, Helen, Cain, Peter, Levenga, Josien, Cowansage, Kiriana K., Choi, Yoon, Davy, Camille, Majmundar, Neil, McMillan, D. Randy, Rothermel, Beverly A., Klann, Eric
Publicado em 2013

“... phosphorylation of a CaN substrate, cAMP response element-binding protein (CREB), in the brains of Rcan1 knock-out...”
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