Resultados da pesquisa - (( drug does develop them ) OR ((( drug doses level ther ) OR ( drug dose level ther ))))

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141

Therapeutic Effect of Sodium Iodide Symporter Gene Therapy Combined With External Beam Radiotherapy and Targeted Drugs That Inhibit DNA Repair

Therapeutic Effect of Sodium Iodide Symporter Gene Therapy Combined With External Beam Radiotherapy and Targeted Drugs That Inhibit DNA Repair

Por Hingorani, Mohan, White, Christine L, Zaidi, Shane, Pandha, Hardev S, Melcher, Alan A, Bhide, Shreerang A, Nutting, Christopher M, Syrigos, Konstantinos N, Vile, Richard G, Vassaux, Georges, Harrington, Kevin J
Publicado em 2010

“..., but relatively low levels of transduction and subsequent radioisotope uptake limit the efficacy of the approach...”
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142

Effect of low dose of intrathecal pethidine on the incidence and intensity of shivering during cesarean section under spinal anesthesia: a randomized, placebo-controlled, double-blind clinical trial

Effect of low dose of intrathecal pethidine on the incidence and intensity of shivering during...

Por Shami, Shoaleh, Nasseri, Karim, Shirmohammadi, Mousa, Sarshivi, Farzad, Ghadami, Negin, Ghaderi, Ebrahim, Pouladi, Mokhtar, Barzanji, Arvin
Publicado no Drug Des Devel Ther (2016)

“... of two different doses of intrathecal pethidine on the incidence and intensity of shivering and other...”
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143

Population Pharmacokinetics of Busulfan in Pediatric and Young Adult Patients Undergoing Hematopoietic Cell Transplant: A Model-Based Dosing Algorithm for Personalized Therapy and Implementation into Routine Clinical Use

Population Pharmacokinetics of Busulfan in Pediatric and Young Adult Patients Undergoing Hematopoietic Cell Transplant: A Model-Based Dosing Algorithm for Personalized Therapy and Implementation...

Por Long-Boyle, Janel, Savic, Rada, Yan, Shirley, Bartelink, Imke, Musick, Lisa, French, Deborah, Law, Jason, Horn, Biljana, Cowan, Morton J., Dvorak, Christopher C.
Publicado no Ther Drug Monit (2015)

“... dosing of busulfan in children undergoing HCT. PATIENTS AND METHODS: Model development was conducted...”
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144

Assessing the potential impact of non-proprietary drug copies on quality of medicine and treatment in patients with relapsing multiple sclerosis: the experience with fingolimod

Assessing the potential impact of non-proprietary drug copies on quality of medicine and treatment...

Por Correale, Jorge, Chiquete, Erwin, Milojevic, Snezana, Frider, Nadina, Bajusz, Imre
Publicado em 2014

“... their efficacy and safety is difficult as regulators may approve nonproprietary drugs without bioequivalence data...”
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145

Steady–state nevirapine, lamivudine and stavudine levels in Malawian HIV-infected children on antiretroviral therapy using split Triomune 30® tablets

Steady–state nevirapine, lamivudine and stavudine levels in Malawian HIV-infected children on antiretroviral therapy using split Triomune 30® tablets

Por Poerksen, Goenke, Pollock, Louisa, Moons, Peter, Chesshyre, Emily, Burger, David, Khoo, Saye, Molyneux, Elizabeth
Publicado em 2010

“... children have been started on ART with split tablets of an adult fixed-dose combination drug in the past...”
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146

Genetic Pharmacotherapy as an Early CNS Drug Development Strategy: Testing Glutaminase Inhibition for Schizophrenia Treatment in Adult Mice

Genetic Pharmacotherapy as an Early CNS Drug Development Strategy: Testing Glutaminase Inhibition for Schizophrenia Treatment in Adult Mice

Por Mingote, Susana, Masson, Justine, Gellman, Celia, Thomsen, Gretchen M., Lin, Chyuan-Sheng, Merker, Robert J., Gaisler-Salomon, Inna, Wang, Yvonne, Ernst, Rachel, Hen, René, Rayport, Stephen
Publicado no Front Syst Neurosci (2016)

“...Genetic pharmacotherapy is an early drug development strategy for the identification of novel CNS...”
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147

Curcumin Inhibits the Activation of Immunoglobulin E-Mediated Mast Cells and Passive Systemic Anaphylaxis in Mice by Reducing Serum Eicosanoid and Histamine Levels

Curcumin Inhibits the Activation of Immunoglobulin E-Mediated Mast Cells and Passive Systemic Anaphylaxis in Mice by Reducing Serum Eicosanoid and Histamine Levels

Por Li, Xian, Lu, Yue, Jin, Ye, Son, Jong-Keun, Lee, Seung Ho, Chang, Hyeun Wook
Publicado em 2014

“... basis for drug development for the treatment of allergic inflammatory diseases....”
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148

Effect of Hypothermia and Targeted Temperature Management on Drug Disposition and Response Following Cardiac Arrest: A Comprehensive Review of Preclinical and Clinical Investigations

Effect of Hypothermia and Targeted Temperature Management on Drug Disposition and Response...

Por Anderson, Kacey B., Poloyac, Samuel M., Kochanek, Patrick M., Empey, Philip E.
Publicado no Ther Hypothermia Temp Manag (2016)

“.... Hypothermia also has been shown to potentially decrease the effect of specific drugs at the receptor level...”
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149

Prescription channeling of COX-2 inhibitors and traditional nonselective nonsteroidal anti-inflammatory drugs: a population-based case–control study

Prescription channeling of COX-2 inhibitors and traditional nonselective nonsteroidal anti-inflammatory drugs: a population-based case–control study

Por Moride, Yola, Ducruet, Thierry, Boivin, Jean-François, Moore, Nicholas, Perreault, Sylvie, Zhao, Sean
Publicado em 2005

“... level, Chronic Disease Score, prior use of low-dose acetylsalicylic acid, acetaminophen, antidepressants...”
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150

Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat Gouty Arthritis by suppressing inflammation: results of a randomized, dose-ranging study

Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat Gouty Arthritis by suppressing inflammation: results of a randomized, dose...

Por Schlesinger, Naomi, De Meulemeester, Marc, Pikhlak, Andrey, Yücel, A Eftal, Richard, Dominik, Murphy, Valda, Arulmani, Udayasankar, Sallstig, Peter, So, Alexander
Publicado em 2011

“...-steroidal anti-inflammatory drugs and/or colchicine were randomized to receive a single subcutaneous dose...”
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151

Managing Strategies for Diverse Diseases: Challenges from Bench to Bedside Translation in Successful Drug Discovery and Development (Part C)

Managing Strategies for Diverse Diseases: Challenges from Bench to Bedside Translation in Successful Drug Discovery and Development (Part C)

Por Kamal, Mohammad A., Greig, Nigel H.
Publicado no Curr Pharm Des (2016)

“... are continuously being made across areas, but how does one optimally combine and focus them to maximize...”
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152

THE INFLUENCE OF POSTNATAL DEVELOPMENT ON DRUG-INDUCED HEPATIC PORPHYRIA AND THE SYNTHESIS OF CYTOCHROME P-450 : A BIOCHEMICAL AND MORPHOLOGICAL STUDY

THE INFLUENCE OF POSTNATAL DEVELOPMENT ON DRUG-INDUCED HEPATIC PORPHYRIA AND THE SYNTHESIS OF CYTOCHROME P-450 : A BIOCHEMICAL AND MORPHOLOGICAL STUDY

Por Song, Chull S., Moses, Harold L., Rosenthal, Alan S., Gelb, Nancy A., Kappas, Attallah
Publicado em 1971

“... inducers of hepatic ALAS does, however, develop in neonatal animals so that by approximately 5–6 wk of age...”
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153

Lack of QT Prolongation for 2′-O-Methoxyethyl-Modified Antisense Oligonucleotides Based on Retrospective Exposure/Response Analysis of Ten Phase 1 Dose-Escalation Placebo-Controlled Studies in Healthy Subjects

Lack of QT Prolongation for 2′-O-Methoxyethyl-Modified Antisense Oligonucleotides Based on Retrospective Exposure/Response Analysis of Ten Phase 1 Dose-Escalation Placebo-Controlled Studies in Healthy...

Por Yu, Rosie Z., Gunawan, Rudy, Geary, Richard S., Hughes, Steven G., Henry, Scott P., Wang, Yanfeng
Publicado no Nucleic Acid Ther (2017)

“... relevant dose levels....”
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154

Efflux pumps of Gram-negative bacteria: what they do, how they do it, with what and how to deal with them

Efflux pumps of Gram-negative bacteria: what they do, how they do it, with what and how to deal with them

Por Amaral, Leonard, Martins, Ana, Spengler, Gabriella, Molnar, Joseph
Publicado em 2014

“... to an antibiotic are also discussed. Lastly, the methods that have been developed for the identification...”
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155

The association between antibody levels before and after 7-valent pneumococcal conjugate vaccine immunization and subsequent pneumococcal infection in chronic arthritis patients

The association between antibody levels before and after 7-valent pneumococcal conjugate vaccine...

Por Nagel, Johanna, Geborek, Pierre, Saxne, Tore, Jönsson, Göran, Englund, Martin, Petersson, Ingemar F, Nilsson, Jan-Åke, Truedsson, Lennart, Kapetanovic, Meliha C
Publicado no Arthritis Res Ther (2015)

“... monotherapy (n = 158) and non-steroidal anti-inflammatory drugs (NSAIDs)/analgesics (n = 85). Antibody levels...”
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156

Effectiveness and metabolic complications after 96 weeks of a generic fixed-dose combination of stavudine, lamivudine, and nevirapine among antiretroviral-naive advanced HIV-infected patients in Thailand: A prospective study

Effectiveness and metabolic complications after 96 weeks of a generic fixed-dose combination...

Por Manosuthi, Weerawat, Sungkanuparph, Somnuek, Tansuphaswadikul, Somsit, Prasithsirikul, Wisit, Athichathanabadi, Chatiya, Likanonsakul, Sirirat, Chaovavanich, Achara
Publicado em 2008

“...Background: Generic fixed-dose combination (FDC) antiretroviral therapy (ART) has been widely used...”
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157

Patient-level pooled analysis of adjudicated gastrointestinal outcomes in celecoxib clinical trials: meta-analysis of 51,000 patients enrolled in 52 randomized trials

Patient-level pooled analysis of adjudicated gastrointestinal outcomes in celecoxib clinical trials...

Por Moore, Andrew, Makinson, Geoffrey, Li, Chunming
Publicado em 2013

“... on complications affecting the entire (upper and lower) gastrointestinal (GI) tract, with no patient-level pooled...”
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158

Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays

Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays

Por Berry, Sarah L., Hameed, Hamza, Thomason, Anna, Maciej-Hulme, Marissa L., Saif Abou-Akkada, Somaia, Horrocks, Paul, Price, Helen P.
Publicado no PLoS Negl Trop Dis (2018)

“..., and resistance to them is emerging. New therapeutics are urgently needed, however, screening the infective...”
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159

TGFβ-induced switch from adipogenic to osteogenic differentiation of human mesenchymal stem cells: identification of drug targets for prevention of fat cell differentiation

TGFβ-induced switch from adipogenic to osteogenic differentiation of human mesenchymal stem cells: identification of drug targets for prevention of fat cell differentiation

Por van Zoelen, Everardus J., Duarte, Isabel, Hendriks, José M., van der Woning, Sebastian P.
Publicado no Stem Cell Res Ther (2016)

“... of HDAC5 levels plays an important role in the inhibitory effect of TGFβ on osteogenic differentiation...”
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160

Effect of preoperative loading dose ticagrelor and clopidogrel on no-reflow phenomenon during intervention in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a systematic review and meta-analysis

Effect of preoperative loading dose ticagrelor and clopidogrel on no-reflow phenomenon during...

Por Dai, Weiran, Ye, Ziliang, Li, Lang, Su, Qiang
Publicado no Drug Des Devel Ther (2018)

“...-analysis to assess the effect of preoperative loading dose ticagrelor and clopidogrel on no-reflow (NRF...”
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