Resultados da pesquisa - ((((drug de) OR (drug dna))v) OR (((drug de) OR (drug dna)))) ((devel ther) OR (novel thr))*

101

Rucaparib: a novel PARP inhibitor for BRCA advanced ovarian cancer

Por Colombo, Ilaria, Lheureux, Stephanie, Oza, Amit Manulal
Publicado no Drug Des Devel Ther (2018)

“... (PARP-1, PARP-2 and PARP-3) that play an important role in repairing DNA damage and maintaining genomic...”
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102

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Targeted inhibition of mammalian target of rapamycin (mTOR) enhances radiosensitivity in pancreatic carcinoma cells

Por Dai, Zhi-Jun, Gao, Jie, Kang, Hua-Feng, Ma, Yu-Guang, Ma, Xiao-Bin, Lu, Wang-Feng, Lin, Shuai, Ma, Hong-Bing, Wang, Xi-Jing, Wu, Wen-Ying
Publicado em 2013

“... of action. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and colony formation...”
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103

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Mechanisms underlying probucol-induced hERG-channel deficiency

Por Shi, Yuan-Qi, Yan, Cai-Chuan, Zhang, Xiao, Yan, Meng, Liu, Li-Rong, Geng, Huai-Ze, Lv, Lin, Li, Bao-Xin
Publicado no Drug Des Devel Ther (2015)

“... arrhythmias (torsades de pointes) or sudden death. Probucol is a cholesterol-lowering drug that could reduce...”
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104

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Isolation and evaluation of anticancer efficacy of stigmasterol in a mouse model of DMBA-induced skin carcinoma

Por Ali, Huma, Dixit, Savita, Ali, Daoud, Alqahtani, Saeed M, Alkahtani, Saad, Alarifi, Saud
Publicado no Drug Des Devel Ther (2015)

“... dismutase, and catalase as compared with the control. Elevated levels of lipid peroxide and DNA damage...”
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105

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Sildenafil potentiates the antitumor activity of cisplatin by induction of apoptosis and inhibition of proliferation and angiogenesis

Por El-Naa, Mona Mohamed, Othman, Mohamed, Younes, Sheren
Publicado no Drug Des Devel Ther (2016)

“...Sildenafil is the first phosphodiesterase-5 inhibitor used for the treatment of erectile...”
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106

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Antimutagenic and antioxidant activity of novel 4-substituted phenyl-2,2′-bichalcophenes and aza-analogs

Por El-Sayed, Wael M, Hussin, Warda A
Publicado em 2013

“... of great interest for the development of novel therapeutics for many diseases including cancer. Ten novel...”
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107

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Baracle(®) vs Baraclude(®) for 48 weeks in patients with treatment-naïve chronic hepatitis B: a comparison of efficacy and safety

Por Kim, Do Young, Kim, Ju Hyun, Tak, Won Young, Yeon, Jong Eun, Lee, Joon Hyeok, Yoon, Jung Hwan, Lee, Youn Jae, Lee, Byung Seok, Han, Byung Hoon, Lee, Han Chu
Publicado no Drug Des Devel Ther (2017)

“..., comparative trial, 118 treatment-naïve patients with CHB were randomly assigned to receive either 0.5 mg...”
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108

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Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung c...

Por Ren, Tao, Shan, Jinlu, Li, Mengxia, Qing, Yi, Qian, Chengyuan, Wang, Guangjie, Li, Qing, Lu, Guoshou, Li, Chongyi, Peng, Yu, Luo, Hao, Zhang, Shiheng, Yang, Yuxing, Cheng, Yi, Wang, Dong, Zhou, Shu-Feng
Publicado no Drug Des Devel Ther (2015)

“... the proapoptotic activity of CDDP in A549 cells. AT-101 also enhanced the inhibitory effect of CDDP on DNA repair...”
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109

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Ursolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway

Por Wu, Shouhai, Zhang, Tianpeng, Du, Jingsheng
Publicado no Drug Des Devel Ther (2016)

“...BACKGROUND: Combinations of adjuvant sensitizers with anticancer drugs is a promising new strategy...”
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110

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Influence of caffeine and hyaluronic acid on collagen biosynthesis in human skin fibroblasts

Por Donejko, Magdalena, Przylipiak, Andrzej, Rysiak, Edyta, Głuszuk, Katarzyna, Surażyński, Arkadiusz
Publicado em 2014

“... fibroblast cultures that had been treated with 1, 2, and 5 mM caffeine and with caffeine and 500 μg/mL HA...”
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111

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Functional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease 1/redox factor-1

Por Sui, Jiangdong, Li, Mengxia, Qian, Chengyuan, Wang, Shufeng, Cheng, Yi, Chen, Benjamin PC, Wang, Dong
Publicado no Drug Des Devel Ther (2014)

“... possessing both DNA repair and redox regulatory activities. It has been shown that blocking redox function...”
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112

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Metformin Disrupts Crosstalk Between G protein-Coupled Receptor and Insulin Receptor Signaling Systems and Inhibits Pancreatic Cancer Growth

Por Kisfalvi, Krisztina, Eibl, Guido, Sinnett-Smith, James, Rozengurt, Enrique
Publicado em 2009

“... of metformin (0.1-0.5 mM) blocked stimulation of DNA synthesis, anchorage-dependent and independent growth...”
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113

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Concomitant food intake does not affect the efficacy of entecavir in chronic hepatitis B patients with virological response: a randomized, multicenter, noninferiority trial

Por Cho, Eun Ju, Yu, Su Jong, Kwon, So Young, Kim, Ji-Hoon, Kim, Do Young, Kim, Won, Lee, June Sung, Lee, Jin Woo, Lee, Youn Jae, Chae, Hee Bok, Yoon, Jung-Hwan
Publicado no Drug Des Devel Ther (2018)

“... and showed a serum HBV DNA level of <20 IU/mL were randomized to take entecavir either under the fasted...”
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114

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Adjuvant therapies for Parkinson’s disease: critical evaluation of safinamide

Por Stocchi, Fabrizio, Torti, Margherita
Publicado no Drug Des Devel Ther (2016)

“...Safinamide (SAF) is a new drug developed for the treatment of Parkinson’s disease (PD). It is a...”
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115

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Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line

Por Ali, Norlaily Mohd, Akhtar, M Nadeem, Ky, Huynh, Lim, Kian Lam, Abu, Nadiah, Zareen, Seema, Ho, Wan Yong, Alan-Ong, Han Kiat, Tan, Sheau Wei, Alitheen, Noorjahan Banu, Ismail, Jamil bin, Yeap, Swee Keong, Kamarul, Tunku
Publicado no Drug Des Devel Ther (2016)

“... treated with 36 μM of FLS displayed cell shrinkage, apoptotic body, and DNA fragmentation. Additionally...”
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116

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Cytoprotective effect of selective small-molecule caspase inhibitors against staurosporine-induced apoptosis

Por Wu, Jianghong, Wang, Yuren, Liang, Shuguang, Ma, Haiching
Publicado em 2014

“... membrane potential. DNA microarray analysis demonstrated that staurosporine treatment induced broad global...”
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117

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Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated...

Por Ren, Tao, Shan, Jinlu, Qing, Yi, Qian, Chengyuan, Li, Qing, Lu, Guoshou, Li, Mengxia, Li, Chongyi, Peng, Yu, Luo, Hao, Zhang, Shiheng, Zhang, Weiwei, Wang, Dong, Zhou, Shu-Feng
Publicado no Drug Des Devel Ther (2014)

“... the STAT3–DNA binding; and reducing the expression of the downstream antiapoptotic proteins Bcl-2 and Bcl...”
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118

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Pancreatic cancer: optimizing treatment options, new, and emerging targeted therapies

Por Chiorean, Elena Gabriela, Coveler, Andrew L
Publicado no Drug Des Devel Ther (2015)

“... the second leading cause of cancer-related deaths in the next decade. Despite 5-fluorouracil/leucovorin...”
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119

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Novel A20-gene-eluting stent inhibits carotid artery restenosis in a porcine model

Por Zhou, Zhen-hua, Peng, Jing, Meng, Zhao-you, Chen, Lin, Huang, Jia-Lu, Huang, He-qing, Li, Li, Zeng, Wen, Wei, Yong, Zhu, Chu-Hong, Chen, Kang-Ning
Publicado no Drug Des Devel Ther (2016)

“... and anti-DNA immunoglobulin fixation. Anti-restenosis effects of modified vs control (the bare-metal stent...”
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120

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Decitabine reverses TGF-β1-induced epithelial–mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis

Por Zhang, Nan, Liu, Yanyang, Wang, Yuyi, Zhao, Maoyuan, Tu, Li, Luo, Feng
Publicado no Drug Des Devel Ther (2017)

“... determined the effect of decitabine, a DNA methyltransferase inhibitor, on TGF-β1-induced EMT in non-small...”
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