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1

A computational pipeline for the development of multi-marker bio-signature panels and ensemble classifiers

A computational pipeline for the development of multi-marker bio-signature panels and ensemble classifiers

Por Günther, Oliver P, Chen, Virginia, Freue, Gabriela Cohen, Balshaw, Robert F, Tebbutt, Scott J, Hollander, Zsuzsanna, Takhar, Mandeep, McMaster, W Robert, McManus, Bruce M, Keown, Paul A, Ng, Raymond T
Publicado em 2012

“... allograft rejection as a case study, we address the following question in this paper: Can acute rejection...”
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2

MRI of the lung (2/3). Why … when … how?

MRI of the lung (2/3). Why … when … how?

Por Biederer, J., Beer, M., Hirsch, W., Wild, J., Fabel, M., Puderbach, M., Van Beek, E. J. R.
Publicado em 2012

“... the latest to be introduced into clinical practice. Its value to replace X-ray and computed tomography (CT...”
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3

Future Directions for Postdoctoral Training in Cancer Prevention: Insights from a Panel of Experts

Future Directions for Postdoctoral Training in Cancer Prevention: Insights from a Panel of Experts

Por Nelson, David E., Faupel-Badger, Jessica, Phillips, Siobhan, Belcher, Britni, Chang, Shine, Abrams, David B., Kramer, Barnett S., White, Mary C., O’Malley, Michael, Varanasi, Arti P., Fabian, Carol J., Wiest, Jonathan S., Colditz, Graham A., Hall, Kara, Shields, Peter G., Weitzel, Jeffrey N.
Publicado em 2014

“... Institute facilitated a meeting by a panel of experts in April 2013 to consider four important topics...”
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4

A framework for analytical characterization of monoclonal antibodies based on reactivity profiles in different tissues

A framework for analytical characterization of monoclonal antibodies based on reactivity profiles in different tissues

Por Rossin, Elizabeth, Lin, Tsung-I, Ho, Hsiu J., Mentzer, Steven J., Pyne, Saumyadipta
Publicado em 2011

“... of the fitted mAb profiles using a skew t mixture of non-linear regression model that can handle intersample...”
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5

A computational pipeline for quantification of pulmonary infections in small animal models using serial PET-CT imaging

A computational pipeline for quantification of pulmonary infections in small animal models using serial PET-CT imaging

Por Bagci, Ulas, Foster, Brent, Miller-Jaster, Kirsten, Luna, Brian, Dey, Bappaditya, Bishai, William R, Jonsson, Colleen B, Jain, Sanjay, Mollura, Daniel J
Publicado em 2013

“... and functional characterizations is needed. For non-invasive imaging techniques such as computed tomography (CT...”
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6

MULTISCREEN SERUM ANALYSIS OF HIGHLY SENSITIZED RENAL DIALYSIS PATIENTS FOR ANTIBODIES TOWARD PUBLIC AND PRIVATE CLASS I HLA DETERMINANTS: IMPLICATIONS FOR COMPUTER-PREDICTED ACCEPTABLE AND UNACCEPTABLE DONOR MISMATCHES IN KIDNEY TRANSPLANTATION

MULTISCREEN SERUM ANALYSIS OF HIGHLY SENSITIZED RENAL DIALYSIS PATIENTS FOR ANTIBODIES TOWARD PUBLIC AND PRIVATE CLASS I HLA DETERMINANTS: IMPLICATIONS FOR COMPUTER-PREDICTED ACCEPTABLE...

Por Duquesnoy, Rene J., White, Linda T., Fierst, Janet W., Vanek, Marian, Banner, Barbara F., Iwaki, Yuichi, Starzl, Thomas E.
Publicado em 1990

“... is based on a 2 × 2 table analysis of correlations between serum reactivity with an HLA-typed cell panel...”
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7

Compound Ranking Based on a New Mathematical Measure of Effectiveness Using Time Course Data from Cell-Based Assays

Compound Ranking Based on a New Mathematical Measure of Effectiveness Using Time Course Data from Cell-Based Assays

Por Diaz, Francisco J., McDonald, Peter R., Roy, Anuradha, Taylor, Byron, Price, Ashleigh, Hall, Jessica, Blagg, Brian S.J., Chaguturu, Rathnam
Publicado em 2013

“... are tested. This article proposes a new approach to measure drug effectiveness, which allows ranking...”
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8

Clinical Implications of Human Population Differences in Genome-Wide Rates of Functional Genotypes

Clinical Implications of Human Population Differences in Genome-Wide Rates of Functional Genotypes

Por Torkamani, Ali, Pham, Phillip, Libiger, Ondrej, Bansal, Vikas, Zhang, Guangfa, Scott-Van Zeeland, Ashley A., Tewhey, Ryan, Topol, Eric J., Schork, Nicholas J.
Publicado em 2012

“... genomes. We pursued this exploration in two major steps. We first considered variation in the per-genome...”
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9

An Image Processing System for Cardiovascular Wall Motion Studies

An Image Processing System for Cardiovascular Wall Motion Studies

Por Covvey, H.D., McLaughlin, P., Tsotsos, J.K., Ridsdale, G., Wigle, E.D.
Publicado em 1980

Assuntos: “...Data Processing in Cardiology II...”
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10

FDG-PET and Neuropsychiatric Symptoms among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging

FDG-PET and Neuropsychiatric Symptoms among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging

Por Krell-Roesch, Janina, Ruider, Hanna, Lowe, Val J., Stokin, Gorazd B., Pink, Anna, Roberts, Rosebud O., Mielke, Michelle M., Knopman, David S., Christianson, Teresa J., Machulda, Mary M., Jack, Clifford R., Petersen, Ronald C., Geda, Yonas E.
Publicado no J Alzheimers Dis (2016)

“... (OR = 2.12; 1.23–3.64); the point estimate was further elevated for APOE ɛ4 carriers (OR = 2.59; 1.00–6.69...”
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11

Normal patellofemoral kinematic patterns during daily activities in dogs

Normal patellofemoral kinematic patterns during daily activities in dogs

Por Moore, Erica J., Kim, Stanley E., Banks, Scott A., Pozzi, Antonio, Coggeshall, Jason D., Jones, Stephen C.
Publicado no BMC Vet Res (2016)

“... computed tomography (CT) of their hind limbs to create 3-D models of the patella and femur. Normal stifle...”
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12

Noninvasive Image Texture Analysis Differentiates K-ras Mutation from Pan-Wildtype NSCLC and Is Prognostic

Noninvasive Image Texture Analysis Differentiates K-ras Mutation from Pan-Wildtype NSCLC and Is Prognostic

Por Weiss, Glen J., Ganeshan, Balaji, Miles, Kenneth A., Campbell, David H., Cheung, Philip Y., Frank, Samuel, Korn, Ronald L.
Publicado em 2014

“... NSCLC was analyzed on the LungCarta Panel. Cases with a K-ras mutation or pan-wildtype for 26 oncogenes...”
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13

Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer

Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer

Por Alexandria C. Rutkovsky, Elizabeth S. Yeh, Stephen T. Guest, Victoria J. Findlay, Robin C. Muise-Helmericks, Kent Armeson, Stephen P. Ethier
Publicado em 2019-05-01

“...EBP1 is predicted to be an essential driving oncogene in many cancer cell lines in vitro, and can act...”
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14

A Fast Method that Uses Polygenic Scores to Estimate the Variance Explained by Genome-wide Marker Panels and the Proportion of Variants Affecting a Trait

A Fast Method that Uses Polygenic Scores to Estimate the Variance Explained by Genome-wide Marker Panels and the Proportion of Variants Affecting a Trait

Por Palla, Luigi, Dudbridge, Frank
Publicado no Am J Hum Genet (2015)

“... are very computationally intensive. Here we propose a fast analytic method that uses polygenic scores...”
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15

Clinical Implications of Human Population Differences in Genome-wide Rates of Functional Genotypes

Clinical Implications of Human Population Differences in Genome-wide Rates of Functional Genotypes

Por Ali eTorkamani, Phillip ePham, Ondrej eLibiger, Vikas eBansal, Guangfa eZhang, Ashley A Scott-Van Zeeland, Ryan eTewhey, Eric J. Topol, Nicholas eSchork
Publicado em 2012-11-01

“... genomes. We pursued this exploration in two major steps. We first considered variation in the per-genome...”
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16

Independent and functional validation of a multi-tumour-type proliferation signature

Independent and functional validation of a multi-tumour-type proliferation signature

Por Starmans, M H W, Lieuwes, N G, Span, P N, Haider, S, Dubois, L, Nguyen, F, van Laarhoven, H W, Sweep, F C G J, Wouters, B G, Boutros, P C, Lambin, P
Publicado em 2012

“... strong prognostic value. As clinical applicability of signatures can be controversial, we sought...”
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17

A high-throughput pipeline for the production of synthetic antibodies for analysis of ribonucleoprotein complexes

A high-throughput pipeline for the production of synthetic antibodies for analysis of ribonucleoprotein complexes

Por Na, Hong, Laver, John D., Jeon, Jouhyun, Singh, Fateh, Ancevicius, Kristin, Fan, Yujie, Cao, Wen Xi, Nie, Kun, Yang, Zhenglin, Luo, Hua, Wang, Miranda, Rissland, Olivia, Westwood, J. Timothy, Kim, Philip M., Smibert, Craig A., Lipshitz, Howard D., Sidhu, Sachdev S.
Publicado no RNA (2016)

“... computationally aided strategy for design of antigens located outside of annotated domains, (ii) high-throughput...”
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18

An extended set of yeast-based functional assays accurately identifies human disease mutations

An extended set of yeast-based functional assays accurately identifies human disease mutations

Por Sun, Song, Yang, Fan, Tan, Guihong, Costanzo, Michael, Oughtred, Rose, Hirschman, Jodi, Theesfeld, Chandra L., Bansal, Pritpal, Sahni, Nidhi, Yi, Song, Yu, Analyn, Tyagi, Tanya, Tie, Cathy, Hill, David E., Vidal, Marc, Andrews, Brenda J., Boone, Charles, Dolinski, Kara, Roth, Frederick P.
Publicado no Genome Res (2016)

“...We can now routinely identify coding variants within individual human genomes. A pressing challenge...”
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19

$Non–high-density lipoprotein fractions are strongly associated with the presence of metabolic syndrome independent of obesity and diabetes: a population-based study among Iranian adults$

Non–high-density lipoprotein fractions are strongly associated with the presence of metabolic...

Por Ghodsi, Saeed, Meysamie, Alipasha, Abbasi, Mehrshad, Ghalehtaki, Reza, Esteghamati, Alireza, Malekzadeh, Masoud M., Asgari, Fereshteh, Gouya, Mohammad M.
Publicado no J Diabetes Metab Disord (2017)

“... in fasting and non-fasting individuals. Metabolic syndrome (MetS) can promote the development of diabetes...”
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20

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Por Dilliott, Allison A., Farhan, Sali M.K., Ghani, Mahdi, Sato, Christine, Liang, Eric, Zhang, Ming, McIntyre, Adam D., Cao, Henian, Racacho, Lemuel, Robinson, John F., Strong, Michael J., Masellis, Mario, Bulman, Dennis E., Rogaeva, Ekaterina, Lang, Anthony, Tartaglia, Carmela, Finger, Elizabeth, Zinman, Lorne, Turnbull, John, Freedman, Morris, Swartz, Rick, Black, Sandra E., Hegele, Robert A.
Publicado no J Vis Exp (2018)

“... the computational burden that often accompanies NGS. Although targeted NGS is restricted to certain regions...”
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