Preparation of (+)- and (−)- B-phenyl- and B-(4-chlorophenyl)-y-butyrolactones: Key Intermediates in the Synthesis of B-phenyl-GABA and Baclofen.

Thepreparationofβ-phenyl-andβ-(4-chlorophenyl)-γ-bu-tyrolactones( ± )-3and( ± )-4andtheirresolutiontothecorrespond-ing(+)-(S)-3, (−)-(R)-3and(+)-(S)-4, (−)-(R)-4throughformation,flashcolumnchromatographyseparationandsubsequenthydrolysisofdiastereoisomeric4-hydroxybutyramides(2’R,3S)-5,(2’R,3R)-5,(2’...

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Gardado en:
Detalles Bibliográficos
Publicado en:Journal of the Mexican Chemical Society
Main Authors: Jazmín Gómez-Gutiérrez, Myriam Meléndez-Rodríguez, Óscar R. Suárez-Castillo, Luis E. Castelán - Duarte, Manuel J. Fragoso-Vázquez, Erick López-Vázquez, Maricruz Sánchez-Zavala
Formato: Artigo
Idioma:Inglês
Publicado: Sociedad Química de México 2015
Assuntos:
Química
Resolution
Diastereoisomeric4
hydroxybutyramides
Phenylγbutyrolactones
Acceso en liña:https://www.redalyc.org/articulo.oa?id=47539242003
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