Comparative analysis of the trypanocidal activity and chemical properties of E-lychnophoric acid and its derivatives using theoretical calculations

E-Lychnophoric acid 1, its derivative ester 2 and alcohol 3 killed 100% of trypomastigoteblood forms of Trypanosoma cruzi at the concentrations of 13.86, 5.68, and 6.48 µg/mL, respectively.Conformational distribution calculations (AM1) of 1, 2 and 3 gave minimum energies for the conformersa, b, c, a...

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Bibliographic Details
Published in:Eclética Química
Main Authors: A. F. C. Alcântara, E. Chiari, A. B. Oliveira, J. E. Guimarães, D. Silveira, D. S. Raslan
Format: Artigo
Language:Inglês
Published: Universidade Estadual Paulista Júlio de Mesquita Filho 2005
Subjects:
Química
DFT calculation
Trypanosoma cruzi
Lychnophora pinaster
trypanocidal activity
caryophyllene derivatives
Online Access:https://www.redalyc.org/articulo.oa?id=42930305
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