Gene homozygosis and mitotic recombination induced by camptothecin and irinotecan in Aspergillus nidulans diploid cells

Mitotic recombination is a process involved in carcinogenesis which can lead to genetic loss through the loss of heterozygosity. The recombinogenic potentials of two anticancer drugs topoisomerase I inhibitors, camptothecin (CPT) and irinotecan (CPT-11), were evaluated in the present study. The homo...

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Publicado en:Anais da Academia Brasileira de Ciências
Autores principales: GIOVANA N. M. ESQUISSATO, JULIANE R. DE SANT’ ANNA, CLAUDINÉIA C. S. FRANCO, LÚCIA J. ROSADA, PAULA A. S. R. DOS SANTOS, MARIALBA A. A. DE CASTRO-PRADO
Formato: Artigo
Lenguaje:Inglês
Publicado: Academia Brasileira de Ciências 2014
Materias:
Multidisciplinaria (Ciencias Naturales y Exactas)
Anticancer drugs
homozygotization assay
Acceso en línea:https://www.redalyc.org/articulo.oa?id=32732907012
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