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The Notch Intracellular Domain Can Function as a Coactivator for LEF-1
Notch signaling commences with two ligand-mediated proteolysis events that release the Notch intracellular domain, NICD, from the plasma membrane. NICD then translocates into the nucleus and interacts with the DNA binding protein CSL to activate transcription. We found that NICD expression also pote...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2001
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC99925/ https://ncbi.nlm.nih.gov/pubmed/11604490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.22.7537-7544.2001 |
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