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The Notch Intracellular Domain Can Function as a Coactivator for LEF-1

Notch signaling commences with two ligand-mediated proteolysis events that release the Notch intracellular domain, NICD, from the plasma membrane. NICD then translocates into the nucleus and interacts with the DNA binding protein CSL to activate transcription. We found that NICD expression also pote...

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Detalhes bibliográficos
Main Authors: Ross, David A., Kadesch, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC99925/
https://ncbi.nlm.nih.gov/pubmed/11604490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.22.7537-7544.2001
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