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Translational Silencing of Ceruloplasmin Requires the Essential Elements of mRNA Circularization: Poly(A) Tail, Poly(A)-Binding Protein, and Eukaryotic Translation Initiation Factor 4G

Ceruloplasmin (Cp) is a glycoprotein secreted by the liver and monocytic cells and probably plays roles in inflammation and iron metabolism. We showed previously that gamma interferon (IFN-γ) induced Cp synthesis by human U937 monocytic cells but that the synthesis was subsequently halted by a trans...

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Publicado no:Mol Cell Biol
Principais autores: Mazumder, Barsanjit, Seshadri, Vasudevan, Imataka, Hiroaki, Sonenberg, Nahum, Fox, Paul L.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2001
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99791/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11533233/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.19.6440-6449.2001
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