Translocation-Specific Conformation of Adenylate Cyclase Toxin from Bordetella pertussis Inhibits Toxin-Mediated Hemolysis

Bordetella pertussis adenylate cyclase (AC) toxin belongs to the RTX family of toxins but is the only member with a known catalytic domain. The principal pathophysiologic function of AC toxin appears to be rapid production of intracellular cyclic AMP (cAMP) by insertion of its catalytic domain into...

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Autores principales: Gray, Mary C., Lee, Sang-Jin, Gray, Lloyd S., Zaretzky, Franca R., Otero, Angela S., Szabo, Gabor, Hewlett, Erik L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Enzymes and Proteins
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC99668/
https://ncbi.nlm.nih.gov/pubmed/11566989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.183.20.5904-5910.2001
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