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Cyclin A- and Cyclin E-Cdk Complexes Shuttle between the Nucleus and the Cytoplasm

Cyclins A and E and their partner cyclin-dependent kinases (Cdks) are key regulators of DNA synthesis and of mitosis. Immunofluorescence studies have shown that both cyclins are nuclear and that a proportion of cyclin A is localized to sites of DNA replication. However, recently, both cyclin A and c...

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Bibliographic Details
Main Authors: Jackman, Mark, Kubota, Yumiko, den Elzen, Nicole, Hagting, Anja, Pines, Jonathon
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2002
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC99617/
https://ncbi.nlm.nih.gov/pubmed/11907280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.01-07-0361
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