Wortmannin Potentiates Integrase-Mediated Killing of Lymphocytes and Reduces the Efficiency of Stable Transduction by Retroviruses

Retroviral infection induces integrase-dependent apoptosis in DNA-PK-deficient murine scid lymphocytes. Furthermore, the efficiency of stable transduction of reporter genes is reduced in adherent cell lines that are deficient in cellular DNA-repair proteins known to mediate nonhomologous end joining...

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Detalhes bibliográficos
Main Authors: Daniel, René, Katz, Richard A., Merkel, George, Hittle, James C., Yen, Tim J., Skalka, Anna Marie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC99570/
https://ncbi.nlm.nih.gov/pubmed/11158303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.4.1164-1172.2001
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