Recombinant Actinobacillus actinomycetemcomitans Cytolethal Distending Toxin Proteins Are Required To Interact To Inhibit Human Cell Cycle Progression and To Stimulate Human Leukocyte Cytokine Synthesis

It has recently been discovered that Actinobacillus actinomycetemcomitans, an oral bacterium causing periodontitis, produces cytolethal distending toxin (CDT), a cell cycle-modulating toxin that has three protein subunits: CdtA, CdtB, and CdtC. In this study, we have cloned and expressed each toxin...

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Detalles Bibliográficos
Main Authors: Akifusa, Sumio, Poole, Stephen, Lewthwaite, Jo, Henderson, Brian, Nair, Sean P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Molecular Pathogenesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC98715/
https://ncbi.nlm.nih.gov/pubmed/11500475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.9.5925-5930.2001
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