Francisella tularensis Induces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication

The murine macrophage-like cell line J774.A1 ingests and allows intracellular growth of Francisella tularensis. We demonstrate that, after 24 h of infection, a pronounced cytopathogenicity resulted and the J774 cells were undergoing apoptosis. Despite this host cell apoptosis, no decrease in bacteri...

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Bibliographische Detailangaben
Hauptverfasser: Lai, Xin-He, Golovliov, Igor, Sjöstedt, Anders
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC98551/
https://ncbi.nlm.nih.gov/pubmed/11402018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.7.4691-4694.2001
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