Safety and Immunogenicity of a Proteosome-Shigella flexneri 2a Lipopolysaccharide Vaccine Administered Intranasally to Healthy Adults

We studied the safety and immunogenicity of a Shigella flexneri 2a vaccine comprising native S. flexneri 2a lipopolysaccharide (LPS) complexed to meningococcal outer membrane proteins—proteosomes—in normal, healthy adults. A two-dose series of immunizations was given by intranasal spray, and doses o...

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Autori principali: Fries, Louis F., Montemarano, Andrew D., Mallett, Corey P., Taylor, David N., Hale, Thomas L., Lowell, George H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Microbial Immunity and Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC98531/
https://ncbi.nlm.nih.gov/pubmed/11401998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.7.4545-4553.2001
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