Pyrogenicity and Cytokine-Inducing Properties of Streptococcus pyogenes Superantigens: Comparative Study of Streptococcal Mitogenic Exotoxin Z and Pyrogenic Exotoxin A

Streptococcal mitogenic exotoxin Z (SMEZ), a superantigen derived from Streptococcus pyogenes, provoked expansion of human lymphocytes expressing the Vβ 2, 4, 7 and 8 motifs of T-cell receptor. SMEZ was pyrogenic in rabbits and stimulated the expression of the T-cell activation markers CD69 and cuta...

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Main Authors: Müller-Alouf, Heide, Proft, Thomas, Zollner, Thomas M., Gerlach, Dieter, Champagne, Eric, Desreumaux, Pierre, Fitting, Catherine, Geoffroy-Fauvet, Christiane, Alouf, Joseph E., Cavaillon, Jean-Marc
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Host Response and Inflammation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC98482/
https://ncbi.nlm.nih.gov/pubmed/11349089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.6.4141-4145.2001
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