Immunogenicity and Protective Efficacy of a Plasmodium yoelii Hsp60 DNA Vaccine in BALB/c Mice

The gene encoding the 60-kDa heat shock protein of Plasmodium yoelii (PyHsp60) was cloned into the VR1012 and VR1020 mammalian expression vectors. Groups of 10 BALB/c mice were immunized intramuscularly at 0, 3, and 9 weeks with 100 μg of PyHsp60 DNA vaccine alone or in combination with 30 μg of pmu...

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Bibliografiske detaljer
Main Authors: Sanchez, Gloria I., Sedegah, Martha, Rogers, William O., Jones, Trevor R., Sacci, John, Witney, Adam, Carucci, Daniel J., Kumar, Nirbhay, Hoffman, Stephen L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Fungal and Parasitic Infections
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC98419/
https://ncbi.nlm.nih.gov/pubmed/11349057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.6.3897-3905.2001
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