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Dissociation of Infectivity and Pathogenicity in Borrelia burgdorferi

Clonal Borrelia burgdorferi N40 (cN40) passaged 75 times in vitro (N40-75) infects mice but does not cause disease. N40-75 passaged 45 times further in vitro (N40-120) was no longer infectious and lacked genes encoded on linear plasmids 38 and 28-1, among other differences. These data suggest that B...

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Pubblicato in:Infect Immun
Autori principali: Thomas, Venetta, Anguita, Juan, Samanta, Swapna, Rosa, Patricia A., Stewart, Philip, Barthold, Stephen W., Fikrig, Erol
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2001
Soggetti:
Molecular Pathogenesis
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC98321/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11292785/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.5.3507-3509.2001
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