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Visualizing Pneumococcal Infections in the Lungs of Live Mice Using Bioluminescent Streptococcus pneumoniae Transformed with a Novel Gram-Positive lux Transposon

Animal studies with Streptococcus pneumoniae have provided valuable models for drug development. In order to monitor long-term pneumococcal infections noninvasively in living mice, a novel gram-positive lux transposon cassette, Tn4001 luxABCDE Km(r), that allows random integration of lux genes onto...

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Udgivet i:Infect Immun
Principais autores: Francis, Kevin P., Yu, Jun, Bellinger-Kawahara, Carolyn, Joh, Danny, Hawkinson, Matthew J., Xiao, Grace, Purchio, Tony F., Caparon, Michael G., Lipsitch, Marc, Contag, Pamela R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Bacterial Infections
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC98294/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11292758/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.5.3350-3358.2001
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