Reversal of the CD4(+)/CD8(+) T-Cell Ratio in Lymph Node Cells upon In Vitro Mitogenic Stimulation by Highly Purified, Water-Soluble S3-S4 Dimer of Pertussis Toxin

Pertussis toxin (PT), a holomer consisting of a catalytic S1 subunit and a B oligomer composed of S2-S4 and S3-S4 dimers, held together by the S5 subunit, exerts profound effects on immune cells, including T-cell mitogenicity. While the mitogenic activity of PT was shown to reside fully within the B...

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Bibliographische Detailangaben
Hauptverfasser: Latif, Rauf, de Rosbo, Nicole Kerlero, Amarant, Tany, Rappuoli, Rino, Sappler, Gregor, Ben-Nun, Avraham
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Host Response and Inflammation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC98262/
https://ncbi.nlm.nih.gov/pubmed/11292726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.5.3073-3081.2001
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