Generation and Characterization of a Defined Mutant of Streptococcus suis Lacking Suilysin

A defined allelic-replacement mutant of the sly gene, encoding a thiol-activated cytolysin, from a European isolate of Streptococcus suis serotype 2 was generated and characterized. Unlike the parental strain, it is nonhemolytic, noncytotoxic for cultured macrophage-like cells, avirulent in a mouse...

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Détails bibliographiques
Auteurs principaux: Allen, Andrew G., Bolitho, Steven, Lindsay, Heather, Khan, Shahid, Bryant, Clare, Norton, Pam, Ward, Philip, Leigh, James, Morgan, Jeremy, Riches, Helen, Eastty, Sarah, Maskell, Duncan
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2001
Sujets:
Molecular Pathogenesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC98215/
https://ncbi.nlm.nih.gov/pubmed/11254643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.4.2732-2735.2001
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